Investigation of the Repairing Effect and Mechanism of Oral Degraded Sericin on Liver Injury in Type II Diabetic Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Sericin Peptides
2.3. Rat Feed
2.4. Liver Weight and Organ Body Coefficients
2.5. Extraction of Total Protein from Liver Samples
2.6. Western Blotting
2.7. Determination of Related Inflammatory Factors
2.8. Data Processing
3. Results
3.1. Liver Organ Quality and Organ Coefficient
3.2. Carbohydrate Metabolism Pathway
3.3. Impact on PI3K/AKT Pathway
3.4. Impact on AMPK/ACC Pathway
3.5. Impact on Liver Damage
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group | Liver Mass (g) | Coefficient (%) |
---|---|---|
Normal | 16.38 ± 1.70 | 3.25 ± 0.34 |
Model | 10.86 ± 1.43 ** | 4.35 ± 0.54 ** |
PC | 15.73 ± 2.92 ## | 4.23 ± 0.79 |
LLS | 10.43 ± 1.20 | 4.11 ± 0.49 |
MLS | 10.49 ± 1.33 | 4.23 ± 0.54 |
HLS | 11.90 ± 1.34 # | 4.03 ± 0.73 # |
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Wei, Z.-Z.; Weng, Y.-J.; Zhang, Y.-Q. Investigation of the Repairing Effect and Mechanism of Oral Degraded Sericin on Liver Injury in Type II Diabetic Rats. Biomolecules 2022, 12, 444. https://doi.org/10.3390/biom12030444
Wei Z-Z, Weng Y-J, Zhang Y-Q. Investigation of the Repairing Effect and Mechanism of Oral Degraded Sericin on Liver Injury in Type II Diabetic Rats. Biomolecules. 2022; 12(3):444. https://doi.org/10.3390/biom12030444
Chicago/Turabian StyleWei, Zhen-Zhen, Yu-Jie Weng, and Yu-Qing Zhang. 2022. "Investigation of the Repairing Effect and Mechanism of Oral Degraded Sericin on Liver Injury in Type II Diabetic Rats" Biomolecules 12, no. 3: 444. https://doi.org/10.3390/biom12030444