Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Abstract
:1. Introduction
2. The Structure and Function of Cosmc
3. Roles of Cosmc in Normal Development
3.1. Cosmc Affects Platelet Production
3.2. Cosmc Affects Kidney Development
3.3. Cosmc Affects the Function of Immune Cells
3.3.1. Cosmc and Extended O-glycosylation Are Key Factors Controlling B-Cell Homing and Maintaining B-Cell Immune Tolerance
3.3.2. Cosmc and Extended O-glycosylation Are Key Factors in Maintaining Peripheral T Cells
3.3.3. Cosmc and Extended O-glycosylation Mediate Phagocytosis of Apoptotic Cells by Macrophages
4. Roles of Cosmc in Non-neoplastic Diseases
4.1. Immune Diseases
4.1.1. Immunoglobulin A Nephropathy (IgAN)
4.1.2. Tn Syndrome
4.2. Inflammatory Diseases
4.2.1. Lung Inflammation
4.2.2. Bowel Inflammation
4.3. Neurodegenerative Diseases
4.4. Viral Diseases
5. Cosmc Function in Tumorigenesis
5.1. Regulation of Cell Proliferation
5.2. Regulation of Cell Apoptosis
5.3. Regulation of Cell Migration
5.4. Regulation of Immune Surveillance
5.5. Regulation of Angiogenesis
5.6. Cosmc as Novel Prognosis Biomarker
6. Final Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Location | Funtion | Citation |
---|---|---|
Platelet | Mediates platelet production by affecting the expression and function of platelet glycoproteins. | [16] |
Kidney | Maintains the normal function of podocyte cells in the kidney. | [3] |
B cell | Mediate the homing of B cells by affecting chemokines and can maintain the immune tolerance of B cells. | [17,37] |
T cell | Mediates the homing of T cells and maintains the presence of peripheral T cells. | [38] |
Macrophage cell | Affect the phagocytosis of apoptotic cells by macrophages. | [39] |
Diseases | Effects | Citation |
---|---|---|
Immunoglobulin A Nephropathy | Downregulation of Cosmc expression causes abnormal glycosylation of IgA1, which is involved in the pathogenesis of IGAN. | [53,54] |
Tn syndrome | Loss of Cosmc function causes abnormal expression of Tn antigens, resulting in Tn syndrome. | [16,18] |
Inflammatory pneumonia | Cosmc regulates the glycosylation of airway mucin 5AC via T antigen and plays an important role in the stimulation of T antigen overexpression by the inflammatory factor neutrophil elastase. | [55] |
Inflammatory bowel disease | Cosmc spatially regulates the intestinal microbiota in a region-specific manner, and its functional deficiency causes a decrease in intestinal mucosal MUC2 protein, causing IBD with a sex-specific profile. | [56] |
Alzheimer’s disease | Cosmc mutations cause abnormal glycosylation in late-onset AD and affect the progression of AD. | [57] |
HTLV-1 infection | Cosmc enhances HTLV-1 virus infection between cells by affecting the glycosylation of CD43 and CD45. | [58] |
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Xiang, T.; Qiao, M.; Xie, J.; Li, Z.; Xie, H. Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease. Biomolecules 2022, 12, 1732. https://doi.org/10.3390/biom12121732
Xiang T, Qiao M, Xie J, Li Z, Xie H. Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease. Biomolecules. 2022; 12(12):1732. https://doi.org/10.3390/biom12121732
Chicago/Turabian StyleXiang, Ting, Muchuan Qiao, Jiangbo Xie, Zheng Li, and Hailong Xie. 2022. "Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease" Biomolecules 12, no. 12: 1732. https://doi.org/10.3390/biom12121732