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Biomolecules
Volume 12
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10.3390/biom12101405
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Review

The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals

by
Muthuswamy Sathyabhama
1,†,
Loganathan Chandramani Priya Dharshini
1,†,
Adhimoolam Karthikeyan
2,†,
Senthil Kalaiselvi
3 and
Taesun Min
4,*
1
Department of Biotechnology, PSG College of Arts & Science, Coimbatore 641014, Tamil Nadu, India
2
Subtropical Horticulture Research Institute, Jeju National University, Jeju 63243, Korea
3
Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, Tamil Nadu, India
4
Department of Animal Biotechnology, Jeju National Animal Research Center (JIA) and Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju 63243, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2022, 12(10), 1405; https://doi.org/10.3390/biom12101405
Submission received: 18 August 2022 / Revised: 23 September 2022 / Accepted: 24 September 2022 / Published: 1 October 2022
(This article belongs to the Special Issue Role of Bioactive Compounds in the Regulation of Mitochondria and Oxidative Stress and Their Therapeutic Potential as Anti-cancer Agents)
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Abstract

Oxidative stress and mitochondrial dysfunction are associated with the pathogenesis of several human diseases. The excessive generation of reactive oxygen species (ROS) and/or lack of adequate antioxidant defenses causes DNA mutations in mitochondria, damages the mitochondrial respiratory chain, and alters membrane permeability and mitochondrial defense mechanisms. All these alterations are linked to the development of numerous diseases. Curcumin, an active ingredient of turmeric plant rhizomes, exhibits numerous biological activities (i.e., antioxidant, anti-inflammatory, anticancer, and antimicrobial). In recent years, many researchers have shown evidence that curcumin has the ability to reduce the oxidative stress- and mitochondrial dysfunction-associated diseases. In this review, we discuss curcumin’s antioxidant mechanism and significance in oxidative stress reduction and suppression of mitochondrial dysfunction in mammals. We also discuss the research gaps and give our opinion on how curcumin research in mammals should proceed moving forward.
Keywords: curcumin; mammals; mitochondrial dysfunction; oxidative stress; antioxidant; anti-inflammatory; anticancer; antimicrobial curcumin; mammals; mitochondrial dysfunction; oxidative stress; antioxidant; anti-inflammatory; anticancer; antimicrobial

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MDPI and ACS Style

Sathyabhama, M.; Priya Dharshini, L.C.; Karthikeyan, A.; Kalaiselvi, S.; Min, T. The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals. Biomolecules 2022, 12, 1405. https://doi.org/10.3390/biom12101405

AMA Style

Sathyabhama M, Priya Dharshini LC, Karthikeyan A, Kalaiselvi S, Min T. The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals. Biomolecules. 2022; 12(10):1405. https://doi.org/10.3390/biom12101405

Chicago/Turabian Style

Sathyabhama, Muthuswamy, Loganathan Chandramani Priya Dharshini, Adhimoolam Karthikeyan, Senthil Kalaiselvi, and Taesun Min. 2022. "The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals" Biomolecules 12, no. 10: 1405. https://doi.org/10.3390/biom12101405

APA Style

Sathyabhama, M., Priya Dharshini, L. C., Karthikeyan, A., Kalaiselvi, S., & Min, T. (2022). The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals. Biomolecules, 12(10), 1405. https://doi.org/10.3390/biom12101405

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