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Review

Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes—Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals

Department of Biology and Medical Parasitology, Wroclaw Medical University, 50-345 Wroclaw, Poland
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Academic Editor: Christophe Hano
Biomolecules 2022, 12(1), 98; https://doi.org/10.3390/biom12010098
Received: 29 November 2021 / Revised: 29 December 2021 / Accepted: 4 January 2022 / Published: 7 January 2022
(This article belongs to the Collection Feature Papers in Synthetic Biology and Bioengineering)
Due to the ever-increasing number of multidrug-resistant bacteria, research concerning plant-derived compounds with antimicrobial mechanisms of action has been conducted. Pentacyclic triterpenes, which have a broad spectrum of medicinal properties, are one of such groups. Asiatic acid (AA) and ursolic acid (UA), which belong to this group, exhibit diverse biological activities that include antioxidant, anti-inflammatory, diuretic, and immunostimulatory. Some of these articles usually contain only a short section describing the antibacterial effects of AA or UA. Therefore, our review article aims to provide the reader with a broader understanding of the activity of these acids against pathogenic bacteria. The bacteria in the human body can live in the planktonic form and create a biofilm structure. Therefore, we found it valuable to present the action of AA and UA on both planktonic and biofilm cultures. The article also presents mechanisms of the biological activity of these substances against microorganisms. View Full-Text
Keywords: asiatic acid; ursolic acid; pentacyclic triterpenes; bacterial biofilm; chronic and recurrent infections asiatic acid; ursolic acid; pentacyclic triterpenes; bacterial biofilm; chronic and recurrent infections
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MDPI and ACS Style

Sycz, Z.; Tichaczek-Goska, D.; Wojnicz, D. Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes—Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals. Biomolecules 2022, 12, 98. https://doi.org/10.3390/biom12010098

AMA Style

Sycz Z, Tichaczek-Goska D, Wojnicz D. Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes—Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals. Biomolecules. 2022; 12(1):98. https://doi.org/10.3390/biom12010098

Chicago/Turabian Style

Sycz, Zuzanna, Dorota Tichaczek-Goska, and Dorota Wojnicz. 2022. "Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes—Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals" Biomolecules 12, no. 1: 98. https://doi.org/10.3390/biom12010098

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