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Biomolecules
Volume 11
Issue 8
10.3390/biom11081238
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Article

Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels

by
Claudia Da Venezia
1,
Nayib Hussein
1,
Marcela Hernández
2,3,
Johanna Contreras
4,
Alicia Morales
4,5,
Macarena Valdés
6,7,
Francisca Rojas
1,
Loreto Matamala
4 and
Patricia Hernández-Ríos
4,*
1
Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
2
Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
3
Department of Pathology and Oral Medicine, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
4
Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
5
Center for Epidemiology and Surveillance of Oral Diseases (CESOD), Faculty of Dentistry, University of Chile, Santiago 8420000, Chile
6
Faculty of Medicine, School of Public Health, University of Chile, Santiago 8380453, Chile
7
Center for Climate and Resilience Research CR2, University of Chile, Santiago 8370449, Chile
*
Author to whom correspondence should be addressed.
Biomolecules 2021, 11(8), 1238; https://doi.org/10.3390/biom11081238
Submission received: 12 July 2021 / Revised: 6 August 2021 / Accepted: 16 August 2021 / Published: 19 August 2021
(This article belongs to the Special Issue Biomolecules and Cardiovascular Disease in Women)
Versions Notes

Abstract

Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP levels; however, a CRP systemic and periodontal correlation in gingival crevicular fluid (GCF) and its CVR impact have been barely studied. We aimed to assess the association between periodontal diseases and CVR in a group of adult women, based on serum high-sensitivity CRP (hs-CRP) levels; and secondly, to determine the association between serum and GCF CRP levels. Gingival crevicular fluid and blood samples were obtained from women with periodontitis, gingivitis, and healthy controls. Serum and GCF CRP were determined by turbidimetric method and Luminex technology, respectively. Data were analyzed and adjusted by CVR factors. All women presented moderate CVR, without an evident association between serum hs-CRP levels and periodontal diseases. While serum hs-CRP concentrations did not significantly differ between groups, patients with gingivitis and periodontitis showed higher CRP levels in GCF, which positively correlated to CRP detection in serum.
Keywords: cardiovascular disease; periodontal diseases; non-communicable diseases; C-reactive protein; gingival crevicular fluid; periodontitis; gingivitis; women; cardiovascular risk; biomediators cardiovascular disease; periodontal diseases; non-communicable diseases; C-reactive protein; gingival crevicular fluid; periodontitis; gingivitis; women; cardiovascular risk; biomediators

Share and Cite

MDPI and ACS Style

Da Venezia, C.; Hussein, N.; Hernández, M.; Contreras, J.; Morales, A.; Valdés, M.; Rojas, F.; Matamala, L.; Hernández-Ríos, P. Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels. Biomolecules 2021, 11, 1238. https://doi.org/10.3390/biom11081238

AMA Style

Da Venezia C, Hussein N, Hernández M, Contreras J, Morales A, Valdés M, Rojas F, Matamala L, Hernández-Ríos P. Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels. Biomolecules. 2021; 11(8):1238. https://doi.org/10.3390/biom11081238

Chicago/Turabian Style

Da Venezia, Claudia, Nayib Hussein, Marcela Hernández, Johanna Contreras, Alicia Morales, Macarena Valdés, Francisca Rojas, Loreto Matamala, and Patricia Hernández-Ríos. 2021. "Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels" Biomolecules 11, no. 8: 1238. https://doi.org/10.3390/biom11081238

APA Style

Da Venezia, C., Hussein, N., Hernández, M., Contreras, J., Morales, A., Valdés, M., Rojas, F., Matamala, L., & Hernández-Ríos, P. (2021). Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels. Biomolecules, 11(8), 1238. https://doi.org/10.3390/biom11081238

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