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Review

The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy?

1
Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, D-97080 Würzburg, Germany
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Infochemistry Scientific Center, Laboratory of Chemoinformatics, ITMO University, 191002 Saint-Petersburg, Russia
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Advanced Stroke Center, Shimane University Hospital, 89-1 Enya, Shimane, Izumo 693-8501, Japan
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Comprehensive Heart Failure Q9 Center, University of Würzburg, D-97080 Würzburg, Germany
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Department of Otolaryngology, Hannover Medical School and Cluster of Excellence “Hearing4All”, 30625 Hannover, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Giuseppe Limongelli
Biomolecules 2021, 11(6), 900; https://doi.org/10.3390/biom11060900
Received: 21 April 2021 / Revised: 5 June 2021 / Accepted: 14 June 2021 / Published: 17 June 2021
(This article belongs to the Special Issue Metabolic and Neurotrophic Pathways Driving the Brain-Heart-Axis)
Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction and cognitive decline. While the deposition of amyloid β peptide (Aβ) and the formation of neurofibrillary tangles (NFTs) are the pathological hallmarks of AD-affected brains, the majority of cases exhibits a combination of comorbidities that ultimately lead to multi-organ failure. Of particular interest, it can be demonstrated that Aβ pathology is present in the hearts of patients with AD, while the formation of NFT in the auditory system can be detected much earlier than the onset of symptoms. Progressive hearing impairment may beget social isolation and accelerate cognitive decline and increase the risk of developing dementia. The current review discusses the concept of a brain–ear–heart axis by which Aβ and NFT inhibition could be achieved through targeted supplementation of neurotrophic factors to the cochlea and the brain. Such amyloid inhibition might also indirectly affect amyloid accumulation in the heart, thus reducing the risk of developing AD-associated amyloid cardiomyopathy and cardiovascular disease. View Full-Text
Keywords: Alzheimer’s disease; amyloid cardiomyopathy; heart failure; age-related hearing loss; neurotrophins; blood–brain barrier; blood–labyrinth barrier; spiral ganglion neuron; BDNF; GDNF Alzheimer’s disease; amyloid cardiomyopathy; heart failure; age-related hearing loss; neurotrophins; blood–brain barrier; blood–labyrinth barrier; spiral ganglion neuron; BDNF; GDNF
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MDPI and ACS Style

Shityakov, S.; Hayashi, K.; Störk, S.; Scheper, V.; Lenarz, T.; Förster, C.Y. The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy? Biomolecules 2021, 11, 900. https://doi.org/10.3390/biom11060900

AMA Style

Shityakov S, Hayashi K, Störk S, Scheper V, Lenarz T, Förster CY. The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy? Biomolecules. 2021; 11(6):900. https://doi.org/10.3390/biom11060900

Chicago/Turabian Style

Shityakov, Sergey, Kentaro Hayashi, Stefan Störk, Verena Scheper, Thomas Lenarz, and Carola Y. Förster. 2021. "The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy?" Biomolecules 11, no. 6: 900. https://doi.org/10.3390/biom11060900

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