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Article

Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis

1
L.A. Miller Centre, Recovery and Performance Laboratory, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL A1K 5A1, Canada
2
Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL A1B 3V6, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Lorena Perrone, Carola Yvette Förster and Michiaki Nagai
Biomolecules 2021, 11(4), 504; https://doi.org/10.3390/biom11040504
Received: 5 March 2021 / Revised: 20 March 2021 / Accepted: 24 March 2021 / Published: 26 March 2021
(This article belongs to the Special Issue Metabolic and Neurotrophic Pathways Driving the Brain-Heart-Axis)
Physical sedentarism is linked to elevated levels of circulating cytokines, whereas exercise upregulates growth-promoting proteins such as brain-derived neurotrophic factor (BDNF). The shift towards a ‘repair’ phenotype could protect against neurodegeneration, especially in diseases such as multiple sclerosis (MS). We investigated whether having higher fitness or participating in an acute bout of maximal exercise would shift the balance of BDNF and interleukin-6 (IL-6) in serum samples of people with progressive MS (n = 14), compared to matched controls (n = 8). Participants performed a maximal graded exercise test on a recumbent stepper, and blood samples were collected at rest and after the test. We assessed walking speed, fatigue, and maximal oxygen consumption (V·O2max). People with MS achieved about 50% lower V·O2max (p = 0.003) than controls. At rest, there were no differences in BDNF between MS and controls; however, IL-6 was significantly higher in MS. Higher V·O2max was associated with a shift in BDNF/IL-6 ratio from inflammation to repair (R = 0.7, p = 0.001) when considering both groups together. In the MS group, greater ability to upregulate BDNF was associated with faster walking speed and lower vitality. We present evidence that higher fitness indicates a shift in the balance of blood biomarkers towards a repair phenotype in progressive MS. View Full-Text
Keywords: multiple sclerosis; rehabilitation; fitness; neurodegeneration; inflammation; biomarkers; neurotrophins; brain-derived neurotrophic factor; cytokines; interleukin-6 multiple sclerosis; rehabilitation; fitness; neurodegeneration; inflammation; biomarkers; neurotrophins; brain-derived neurotrophic factor; cytokines; interleukin-6
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MDPI and ACS Style

Devasahayam, A.J.; Kelly, L.P.; Williams, J.B.; Moore, C.S.; Ploughman, M. Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis. Biomolecules 2021, 11, 504. https://doi.org/10.3390/biom11040504

AMA Style

Devasahayam AJ, Kelly LP, Williams JB, Moore CS, Ploughman M. Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis. Biomolecules. 2021; 11(4):504. https://doi.org/10.3390/biom11040504

Chicago/Turabian Style

Devasahayam, Augustine Joshua, Liam Patrick Kelly, John Bradley Williams, Craig Stephen Moore, and Michelle Ploughman. 2021. "Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis" Biomolecules 11, no. 4: 504. https://doi.org/10.3390/biom11040504

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