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TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain

Institute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, D-97070 Wuerzburg, Germany
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Lorena Perrone
Biomolecules 2021, 11(9), 1360;
Received: 14 August 2021 / Revised: 7 September 2021 / Accepted: 10 September 2021 / Published: 14 September 2021
(This article belongs to the Special Issue Metabolic and Neurotrophic Pathways Driving the Brain-Heart-Axis)
Ischemic insults to the heart and brain, i.e., myocardial and cerebral infarction, respectively, are amongst the leading causes of death worldwide. While there are therapeutic options to allow reperfusion of ischemic myocardial and brain tissue by reopening obstructed vessels, mitigating primary tissue damage, post-infarction inflammation and tissue remodeling can lead to secondary tissue damage. Similarly, ischemia in retinal tissue is the driving force in the progression of neovascular eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD), which eventually lead to functional blindness, if left untreated. Intriguingly, the easily observable retinal blood vessels can be used as a window to the heart and brain to allow judgement of microvascular damages in diseases such as diabetes or hypertension. The complex neuronal and endocrine interactions between heart, retina and brain have also been appreciated in myocardial infarction, ischemic stroke, and retinal diseases. To describe the intimate relationship between the individual tissues, we use the terms heart-brain and brain-retina axis in this review and focus on the role of transforming growth factor β (TGFβ) and neurotrophins in regulation of these axes under physiologic and pathologic conditions. Moreover, we particularly discuss their roles in inflammation and repair following ischemic/neovascular insults. As there is evidence that TGFβ signaling has the potential to regulate expression of neurotrophins, it is tempting to speculate, and is discussed here, that cross-talk between TGFβ and neurotrophin signaling protects cells from harmful and/or damaging events in the heart, retina, and brain. View Full-Text
Keywords: heart-brain axis; brain-retina axis; neurotrophins; TGFβ signaling; myocardial infarction; diabetic retinopathy; age-related macular degeneration; ischemic stroke heart-brain axis; brain-retina axis; neurotrophins; TGFβ signaling; myocardial infarction; diabetic retinopathy; age-related macular degeneration; ischemic stroke
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MDPI and ACS Style

Schlecht, A.; Vallon, M.; Wagner, N.; Ergün, S.; Braunger, B.M. TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain. Biomolecules 2021, 11, 1360.

AMA Style

Schlecht A, Vallon M, Wagner N, Ergün S, Braunger BM. TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain. Biomolecules. 2021; 11(9):1360.

Chicago/Turabian Style

Schlecht, Anja, Mario Vallon, Nicole Wagner, Süleyman Ergün, and Barbara M. Braunger 2021. "TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain" Biomolecules 11, no. 9: 1360.

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