HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion

Matsubara, Keiichi; Matsubara, Yuko; Uchikura, Yuka; Takagi, Katsuko; Yano, Akiko; Sugiyama, Takashi

doi:10.3390/biom11060822

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HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion

by

Keiichi Matsubara

^1,*,

Yuko Matsubara

²,

Yuka Uchikura

²,

Katsuko Takagi

²,

Akiko Yano

² and

Takashi Sugiyama

²

¹

Department of Regional Pediatrics and Perinatology, Graduate School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan

²

Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan

^*

Author to whom correspondence should be addressed.

Biomolecules 2021, 11(6), 822; https://doi.org/10.3390/biom11060822

Submission received: 30 April 2021 / Revised: 27 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021

(This article belongs to the Special Issue HMG Proteins from Molecules to Disease)

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Abstract

Preeclampsia (PE) is a serious disease that can be fatal for the mother and fetus. The two-stage theory has been proposed as its cause, with the first stage comprising poor placentation associated with the failure of fertilized egg implantation. Successful implantation and placentation require maternal immunotolerance of the fertilized egg as a semi-allograft and appropriate extravillous trophoblast (EVT) invasion of the decidua and myometrium. The disturbance of EVT invasion during implantation in PE results in impaired spiral artery remodeling. PE is thought to be caused by hypoxia during remodeling failure–derived poor placentation, which results in chronic inflammation. High-mobility group protein A (HMGA) is involved in the growth and invasion of cancer cells and likely in the growth and invasion of trophoblasts. Its mechanism of action is associated with immunotolerance. Thus, HMGA is thought to play a pivotal role in successful pregnancy, and its dysfunction may be related to the pathogenesis of PE. The evaluation of HMGA function and its changes in PE might confirm that it is a reliable biomarker of PE and provide prospects for PE treatment through the induction of EVT proliferation and invasion during the implantation.

Keywords: preeclampsia; HMGA; immunotolerance; extravillous trophoblast; placentation

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MDPI and ACS Style

Matsubara, K.; Matsubara, Y.; Uchikura, Y.; Takagi, K.; Yano, A.; Sugiyama, T. HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion. Biomolecules 2021, 11, 822. https://doi.org/10.3390/biom11060822

AMA Style

Matsubara K, Matsubara Y, Uchikura Y, Takagi K, Yano A, Sugiyama T. HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion. Biomolecules. 2021; 11(6):822. https://doi.org/10.3390/biom11060822

Chicago/Turabian Style

Matsubara, Keiichi, Yuko Matsubara, Yuka Uchikura, Katsuko Takagi, Akiko Yano, and Takashi Sugiyama. 2021. "HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion" Biomolecules 11, no. 6: 822. https://doi.org/10.3390/biom11060822

APA Style

Matsubara, K., Matsubara, Y., Uchikura, Y., Takagi, K., Yano, A., & Sugiyama, T. (2021). HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion. Biomolecules, 11(6), 822. https://doi.org/10.3390/biom11060822

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HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion

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