Next Article in Journal
The ‘Shape-Shifter’ Peptide from the Disulphide Isomerase PmScsC Shows Context-Dependent Conformational Preferences
Next Article in Special Issue
Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host
Previous Article in Journal
Immunohistochemical Analysis of the Expression of Adhesion Proteins: TNS1, TNS2 and TNS3 in Correlation with Clinicopathological Parameters in Gastric Cancer
Previous Article in Special Issue
Phytochemicals as Regulators of Genes Involved in Synucleinopathies

Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
Department for Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapce, 10090 Zagreb, Croatia
School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
School of Medicine, The University of Zagreb, 10000 Zagreb, Croatia
Department of Psychiatry, University Hospital Center Zagreb, 10000 Zagreb, Croatia
Department of Psychiatry, University Hospital Dubrava, 10000 Zagreb, Croatia
Rochester Institute of Technology Croatia, 10000 Zagreb, Croatia
AXON LAB d.o.o., 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Academic Editors: Vladimir N. Uversky and Thomas R. Caulfield
Biomolecules 2021, 11(5), 641;
Received: 8 March 2021 / Revised: 15 April 2021 / Accepted: 24 April 2021 / Published: 26 April 2021
(This article belongs to the Collection Feature Papers in Section Molecular Medicine)
Posttraumatic stress disorder (PTSD) is frequently associated with cognitive disturbances and high prevalence of smoking. This study evaluated cognition in war veterans with PTSD and control subjects, controlled for the effect of smoking and brain derived neurotrophic factor (BDNF) rs6265 and rs56164415 genotypes/alleles. Study included 643 male war veterans with combat related PTSD and 120 healthy controls. Genotyping was done by real time PCR. Cognitive disturbances were evaluated using the Positive and Negative Syndrome Scale (PANSS) cognition subscale and the Rey-Osterrieth Complex Figure (ROCF) test scores. Diagnosis (p < 0.001), BDNF rs56164415 (p = 0.011) and smoking (p = 0.028) were significant predictors of the cognitive decline in subjects with PTSD. BDNF rs56164415 T alleles were more frequently found in subjects with PTSD, smokers and non-smokers, with impaired cognition, i.e., with the higher PANSS cognition subscale scores and with the lower ROCF immediate recall test scores. Presence of one or two BDNF rs56164415 T alleles was related to cognitive decline in PTSD. The T allele carriers with PTSD had advanced cognitive deterioration in smokers and nonsmokers with PTSD, and worse short-term visual memory function. Our findings emphasize the role of the BDNF rs56164415 T allele and smoking in cognitive dysfunction in war veterans with PTSD. View Full-Text
Keywords: PTSD; cognition; BDNF rs6265; BDNF rs56164415; war veterans; smoking PTSD; cognition; BDNF rs6265; BDNF rs56164415; war veterans; smoking
Show Figures

Figure 1

MDPI and ACS Style

Nedic Erjavec, G.; Nikolac Perkovic, M.; Tudor, L.; Uzun, S.; Kovacic Petrovic, Z.; Konjevod, M.; Sagud, M.; Kozumplik, O.; Svob Strac, D.; Peraica, T.; Mimica, N.; Havelka Mestrovic, A.; Zilic, D.; Pivac, N. Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules 2021, 11, 641.

AMA Style

Nedic Erjavec G, Nikolac Perkovic M, Tudor L, Uzun S, Kovacic Petrovic Z, Konjevod M, Sagud M, Kozumplik O, Svob Strac D, Peraica T, Mimica N, Havelka Mestrovic A, Zilic D, Pivac N. Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules. 2021; 11(5):641.

Chicago/Turabian Style

Nedic Erjavec, Gordana, Matea Nikolac Perkovic, Lucija Tudor, Suzana Uzun, Zrnka Kovacic Petrovic, Marcela Konjevod, Marina Sagud, Oliver Kozumplik, Dubravka Svob Strac, Tina Peraica, Ninoslav Mimica, Ana Havelka Mestrovic, Denis Zilic, and Nela Pivac. 2021. "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans" Biomolecules 11, no. 5: 641.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop