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Review

Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies

by 1,2,* and 1,3
1
Radiation-Immuno Oncology Group, TranslaTUM—Central Institute for Translational Cancer Research, Klinikum rechts der Isar, TU München, Einsteinstr. 25, 81675 Munich, Germany
2
Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, China
3
Department of Radiation Oncology, Klinikum rechts der Isar, TU München, 81675 Munich, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Stephan M. Huber
Biomolecules 2021, 11(4), 582; https://doi.org/10.3390/biom11040582
Received: 18 March 2021 / Revised: 7 April 2021 / Accepted: 12 April 2021 / Published: 15 April 2021
(This article belongs to the Special Issue Repurposing Drugs for Anti-Cancer Therapy)
In recent years, evidence has accumulated that cannabinoids—especially the non-psychoactive compound, cannabidiol (CBD)—possess promising medical and pharmacological activities that might qualify them as potential anti-tumor drugs. This review is based on multiple studies summarizing different mechanisms for how CBD can target tumor cells including cannabinoid receptors or other constituents of the endocannabinoid system, and their complex activation of biological systems that results in the inhibition of tumor growth. CBD also participates in anti-inflammatory activities which are related to tumor progression, as demonstrated in preclinical models. Although the numbers of clinical trials and tested tumor entities are limited, there is clear evidence that CBD has anti-tumor efficacy and is well tolerated in human cancer patients. In summary, it appears that CBD has potential as a neoadjuvant and/or adjuvant drug in therapy for cancer. View Full-Text
Keywords: cannabinoids; cannabidiol; anti-tumor therapy cannabinoids; cannabidiol; anti-tumor therapy
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MDPI and ACS Style

Wang, F.; Multhoff, G. Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies. Biomolecules 2021, 11, 582. https://doi.org/10.3390/biom11040582

AMA Style

Wang F, Multhoff G. Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies. Biomolecules. 2021; 11(4):582. https://doi.org/10.3390/biom11040582

Chicago/Turabian Style

Wang, Fei, and Gabriele Multhoff. 2021. "Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies" Biomolecules 11, no. 4: 582. https://doi.org/10.3390/biom11040582

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