Next Article in Journal
Biological Rhythm and Chronotype: New Perspectives in Health
Next Article in Special Issue
Structure and Location of Protein Sites Binding Self-Associated Congo Red Molecules with Intercalated Drugs as Compact Ligands—Theoretical Studies
Previous Article in Journal
AP-64, Encoded by C5orf46, Exhibits Antimicrobial Activity against Gram-Negative Bacteria
Previous Article in Special Issue
Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products
Article

Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database

1
Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller University, Lessing Strasse 8, 07743 Jena, Germany
2
Institute for Bioinformatics and Chemoinformatics, Westphalian University of Applied Sciences, August-Schmidt-Ring 10, 45665 Recklinghausen, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: José L. Medina-Franco
Biomolecules 2021, 11(4), 486; https://doi.org/10.3390/biom11040486
Received: 26 February 2021 / Revised: 19 March 2021 / Accepted: 21 March 2021 / Published: 24 March 2021
Natural products (NPs), biomolecules produced by living organisms, inspire the pharmaceutical industry and research due to their structural characteristics and the substituents from which they derive their activities. Glycosidic residues are frequently present in NP structures and have particular pharmacokinetic and pharmacodynamic importance as they improve their solubility and are often involved in molecular transport, target specificity, ligand–target interactions, and receptor binding. The COlleCtion of Open Natural prodUcTs (COCONUT) is currently the largest open database of NPs, and therefore a suitable starting point for the detection and analysis of the diversity of glycosidic residues in NPs. In this work, we report and describe the presence of circular, linear, terminal, and non-terminal glycosidic units in NPs, together with their importance in drug discovery. View Full-Text
Keywords: natural products; glycosides; bioactivity; glycosidic residues; sugars; carbohydrates; deglycosylation; cheminformatics; Chemistry Development Kit; CDK natural products; glycosides; bioactivity; glycosidic residues; sugars; carbohydrates; deglycosylation; cheminformatics; Chemistry Development Kit; CDK
Show Figures

Figure 1

MDPI and ACS Style

Schaub, J.; Zielesny, A.; Steinbeck, C.; Sorokina, M. Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database. Biomolecules 2021, 11, 486. https://doi.org/10.3390/biom11040486

AMA Style

Schaub J, Zielesny A, Steinbeck C, Sorokina M. Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database. Biomolecules. 2021; 11(4):486. https://doi.org/10.3390/biom11040486

Chicago/Turabian Style

Schaub, Jonas, Achim Zielesny, Christoph Steinbeck, and Maria Sorokina. 2021. "Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database" Biomolecules 11, no. 4: 486. https://doi.org/10.3390/biom11040486

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop