Next Article in Journal
Metallomics Analysis for Assessment of Toxic Metal Burdens in Infants/Children and Their Mothers: Early Assessment and Intervention Are Essential
Previous Article in Journal
Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 11
Issue 1
10.3390/biom11010005
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

by
Noora Houttu
1,*,
Kati Mokkala
1,
Ella Koivuniemi
1,
Outi Pellonperä
2,
Juuso Juhila
3,
Timo Sorsa
4,5 and
Kirsi Laitinen
1
1
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland
2
Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, 20520 Turku, Finland
3
Actim Oy, 02180 Espoo, Finland
4
Department of Oral and Maxillofacial Disease, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland
5
Department of Oral Diseases, Karolinska Institutet, 141 04 Huddinge, Sweden
*
Author to whom correspondence should be addressed.
Biomolecules 2021, 11(1), 5; https://doi.org/10.3390/biom11010005
Submission received: 26 November 2020 / Revised: 12 December 2020 / Accepted: 17 December 2020 / Published: 22 December 2020
(This article belongs to the Section Biological Factors)
Browse Figures
Versions Notes

Abstract

Background: We investigated the impact of fish oil and/or probiotics on serum and vaginal inflammatory and metabolic proteins and their relation to the onset of gestational diabetes mellitus (GDM). Methods: Overweight/obese pregnant women received fish oil + placebo, probiotics + placebo, fish oil + probiotics or placebo + placebo from early pregnancy until six months postpartum (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid; probiotics: Lactobacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 1010 colony-forming units each). Serum high sensitivity C-reactive protein (hsCRP) and serum/vaginal (s/v) phosphorylated insulin-like growth factor binding-protein-1 (phIGFBP-1), IGFBP-1 and matrix metalloproteinase 8 (MMP-8) were analyzed. GDM was diagnosed according to 2 h 75 g OGTT. Results: The intervention had no impact on the change in proteins during pregnancy. Nevertheless, s-MMP-8 decreased and s-IGFBP-1 increased more in obese than in overweight women in the fish oil + probiotics group, while a decrease in s-MMP-8 was seen in obese women and an increase was seen in overweight women in the probiotics + placebo group. The late pregnancy s-phIGFBP-1 was higher in women who developed GDM in fish oil + probiotics-group compared to fish oil + placebo-group. The concentrations of s-phIGFBP-1 (635.9 ± 315.3 ng/mL vs. 753.2 ± 335.1 ng/mL, p = 0.005) and s-IGFBP-1 (3.78 ± 0.72 ng/mL vs. 3.96 ± 0.69 ng/mL, p = 0.042) were lower in early pregnancy in women who developed GDM than in women remaining healthy. Conclusions: The intervention per se had no impact on the proteins, but obesity and GDM may modify the effect. IGFBPs may affect the development of GDM.
Keywords: low-grade inflammation; IGFBP-1; MMP-8; obesity; pregnancy low-grade inflammation; IGFBP-1; MMP-8; obesity; pregnancy

Share and Cite

MDPI and ACS Style

Houttu, N.; Mokkala, K.; Koivuniemi, E.; Pellonperä, O.; Juhila, J.; Sorsa, T.; Laitinen, K. The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Biomolecules 2021, 11, 5. https://doi.org/10.3390/biom11010005

AMA Style

Houttu N, Mokkala K, Koivuniemi E, Pellonperä O, Juhila J, Sorsa T, Laitinen K. The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Biomolecules. 2021; 11(1):5. https://doi.org/10.3390/biom11010005

Chicago/Turabian Style

Houttu, Noora, Kati Mokkala, Ella Koivuniemi, Outi Pellonperä, Juuso Juhila, Timo Sorsa, and Kirsi Laitinen. 2021. "The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial" Biomolecules 11, no. 1: 5. https://doi.org/10.3390/biom11010005

APA Style

Houttu, N., Mokkala, K., Koivuniemi, E., Pellonperä, O., Juhila, J., Sorsa, T., & Laitinen, K. (2021). The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Biomolecules, 11(1), 5. https://doi.org/10.3390/biom11010005

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop