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Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Cheras 56000, Kuala Lumpur, Malaysia
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Biomolecules 2021, 11(1), 42; https://doi.org/10.3390/biom11010042
Received: 15 December 2020 / Revised: 23 December 2020 / Accepted: 27 December 2020 / Published: 30 December 2020
(This article belongs to the Collection Pharmacology of Medicinal Plants)
While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections. View Full-Text
Keywords: dengue virus; medicinal plants; ethnobotany; pharmacology; phytochemical; SARS-CoV dengue virus; medicinal plants; ethnobotany; pharmacology; phytochemical; SARS-CoV
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MDPI and ACS Style

Saleh, M.S.M.; Kamisah, Y. Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus. Biomolecules 2021, 11, 42. https://doi.org/10.3390/biom11010042

AMA Style

Saleh MSM, Kamisah Y. Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus. Biomolecules. 2021; 11(1):42. https://doi.org/10.3390/biom11010042

Chicago/Turabian Style

Saleh, Mohammed S. M., and Yusof Kamisah. 2021. "Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus" Biomolecules 11, no. 1: 42. https://doi.org/10.3390/biom11010042

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