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Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions
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An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
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Biomolecules 2020, 10(9), 1279; https://doi.org/10.3390/biom10091279
Received: 4 August 2020 / Revised: 26 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Oxygen Therapy)
Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke. View Full-Text
Keywords: preconditioning; stem cells; cerebral ischemia; hyperbaric oxygen therapy; neuroprotection preconditioning; stem cells; cerebral ischemia; hyperbaric oxygen therapy; neuroprotection
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MDPI and ACS Style

Cozene, B.; Sadanandan, N.; Gonzales-Portillo, B.; Saft, M.; Cho, J.; Park, Y.J.; Borlongan, C.V. An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic. Biomolecules 2020, 10, 1279.

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