Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions
1
The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel
2
The School of Psychological Sciences, Tel Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(9), 1247; https://doi.org/10.3390/biom10091247
Received: 30 July 2020 / Revised: 19 August 2020 / Accepted: 20 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Oxygen Therapy)
In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100% oxygen gas at a pressure of more than one atmosphere absolute. This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions.
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Keywords:
hyperbaric oxygen therapy; hypoxia; neurological conditions; neurodevelopmental disorders; autistic spectrum disorder; cerebral palsy; traumatic brain injury; mitochondria; white matter; reactive oxygen stress; angiogenesis
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MDPI and ACS Style
Fischer, I.; Barak, B. Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions. Biomolecules 2020, 10, 1247. https://doi.org/10.3390/biom10091247
AMA Style
Fischer I, Barak B. Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions. Biomolecules. 2020; 10(9):1247. https://doi.org/10.3390/biom10091247
Chicago/Turabian StyleFischer, Inbar; Barak, Boaz. 2020. "Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions" Biomolecules 10, no. 9: 1247. https://doi.org/10.3390/biom10091247
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