Next Article in Journal
Phosphate Derivatives of 3-Carboxyacylbetulin: SynThesis, In Vitro Anti-HIV and Molecular Docking Study
Next Article in Special Issue
Naphthoquinone-Based Meroterpenoids from Marine-Derived Streptomyces sp. B9173
Previous Article in Journal
Functionalizable Antifouling Coatings as Tunable Platforms for the Stress-Driven Manipulation of Living Cell Machinery
Previous Article in Special Issue
Regulation of Protein Post-Translational Modifications on Metabolism of Actinomycetes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 10
Issue 8
10.3390/biom10081147
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes

by
Masaya Kobayashi
1 and
Tomohisa Kuzuyama
2,*
1
Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
2
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(8), 1147; https://doi.org/10.3390/biom10081147
Submission received: 4 July 2020 / Revised: 1 August 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Recent Advance of Actinomycetes)
Browse Figures
Versions Notes

Abstract

Structurally diverse carbazole alkaloids are valuable due to their pharmaceutical properties and have been isolated from nature. Experimental knowledge on carbazole biosynthesis is limited. The latest development of in silico analysis of the biosynthetic gene clusters for bacterial carbazoles has allowed studies on the biosynthesis of a carbazole skeleton, which was established by sequential enzyme-coupling reactions associated with an unprecedented carbazole synthase, a thiamine-dependent enzyme, and a ketosynthase-like enzyme. This review describes the carbazole biosynthetic mechanism, which includes a key step in enzymatic formation of a tricyclic carbazole skeleton, followed by modifications such as prenylation and hydroxylation in the skeleton.
Keywords: biosynthesis; carbazoles; cyclization; enzymes; protein structure biosynthesis; carbazoles; cyclization; enzymes; protein structure

Share and Cite

MDPI and ACS Style

Kobayashi, M.; Kuzuyama, T. Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes. Biomolecules 2020, 10, 1147. https://doi.org/10.3390/biom10081147

AMA Style

Kobayashi M, Kuzuyama T. Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes. Biomolecules. 2020; 10(8):1147. https://doi.org/10.3390/biom10081147

Chicago/Turabian Style

Kobayashi, Masaya, and Tomohisa Kuzuyama. 2020. "Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes" Biomolecules 10, no. 8: 1147. https://doi.org/10.3390/biom10081147

APA Style

Kobayashi, M., & Kuzuyama, T. (2020). Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes. Biomolecules, 10(8), 1147. https://doi.org/10.3390/biom10081147

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop