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Article

Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications

1
Department of Surgery and Cancer, Imperial College, London W2 1NY, UK
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Department of Colorectal Surgery, Royal Marsden Hospital, London SW3 6JJ, UK
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Department of Colorectal Surgery, Chelsea and Westminster Hospital, London SW10 9NH, UK
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Lung Pathology Unit, Airway Disease Infection, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
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Department of Cellular Pathology, Imperial College, London W2 1NY, UK
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Department of Metabolism, Digestion, and Reproduction, Imperial College, London W2 1NY, UK
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(8), 1145; https://doi.org/10.3390/biom10081145
Received: 27 June 2020 / Revised: 29 July 2020 / Accepted: 2 August 2020 / Published: 5 August 2020
(This article belongs to the Section Molecular Medicine)
Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical outcomes. Methods: A prospective cohort study which quantifies the protein expression of NTS, NTSR1 and NTSR3 in human CRCs using immunohistochemistry. Expression levels were then compared with clinico-pathological outcome including histological grade, overall survival (OS) and disease-free survival (DFS). Results: Sixty-four patients were enrolled with median follow-up of 44.0 months. There was significantly higher expression of NTS in cancer tissue in CRC with higher T stages (p < 0.01), N stages (p = 0.03), and AJCC clinical stages (p = 0.04). There was significantly higher expression of NTS, NTSR1 and NTSR3 in cancer tissue compared to surrounding normal epithelium (median H-score 163.5 vs 97.3, p < 0.01). There was significantly shorter DFS in individuals with CRC with high levels of NTS compared to lower levels of NTS (35.8 months 95% CI 28.7–42.8 months vs 46.4 months 95% CI 42.2–50.5 months, respectively, p = 0.02). Above median NTS expression in cancer tissue was a significant risk factor for disease recurrence (HR 4.10, 95% CI 1.14–14.7, p = 0.03). Discussion: The expression of NTS and its receptors has the potential to be utilised as a predictive and prognostic marker in colorectal cancer for postoperative selection for adjuvant therapy and identify individuals for novel therapies targeting the neurotensinergic pathways. Conclusions: High NTS expression appears to be associated with more advanced CRC and worse DFS. View Full-Text
Keywords: colorectal cancer; biomarker; neurotensin colorectal cancer; biomarker; neurotensin
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MDPI and ACS Style

Qiu, S.; Nikolaou, S.; Zhu, J.; Jeffery, P.; Goldin, R.; Kinross, J.; Alexander, J.L.; Rasheed, S.; Tekkis, P.; Kontovounisios, C. Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications. Biomolecules 2020, 10, 1145. https://doi.org/10.3390/biom10081145

AMA Style

Qiu S, Nikolaou S, Zhu J, Jeffery P, Goldin R, Kinross J, Alexander JL, Rasheed S, Tekkis P, Kontovounisios C. Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications. Biomolecules. 2020; 10(8):1145. https://doi.org/10.3390/biom10081145

Chicago/Turabian Style

Qiu, Shengyang, Stella Nikolaou, Jie Zhu, Peter Jeffery, Robert Goldin, James Kinross, James L. Alexander, Shahnawaz Rasheed, Paris Tekkis, and Christos Kontovounisios. 2020. "Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications" Biomolecules 10, no. 8: 1145. https://doi.org/10.3390/biom10081145

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