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Article

Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells

1
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany
2
Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
3
Department for Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(7), 1000; https://doi.org/10.3390/biom10071000
Received: 22 May 2020 / Revised: 1 July 2020 / Accepted: 2 July 2020 / Published: 4 July 2020
(This article belongs to the Section Biochemistry)
The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined. In the present study, we evaluated antitumor efficacies of a specific green tea, sencha tea, on sensitive and multidrug-resistant leukemia and a panel of nine multiple myelomas (MM) cell lines. We found that sencha extracts induced cytotoxicity in leukemic cells and MM cells to different extents, yet its effect on normal cells was limited. Furthermore, sencha extracts caused G2/M and G0/G1 phase arrest during cell cycle progression in CCRF/CEM and KMS-12-BM cells, respectively. Specifically, sencha-MeOH/H2O extracts induced apoptosis, ROS, and MMP collapse on both CCRF/CEM and KMS-12-BM cells. The analysis with microarray and COMPARE in 53 cell lines of the NCI panel revealed diverse functional groups, including cell morphology, cellular growth and proliferation, cell cycle, cell death, and survival, which were closely associated with anti-tumor effects of sencha tea. It is important to note that PI3K/Akt and NF-κB pathways were the top two dominant networks by ingenuity pathway analysis. We demonstrate here the multifactorial modes of action of sencha tea leading to chemopreventive effects of sencha tea against cancer. View Full-Text
Keywords: green tea; catechins; chemotherapy; drug resistance; flavonoids; functional food; microarray analysis; natural products; polyphenols green tea; catechins; chemotherapy; drug resistance; flavonoids; functional food; microarray analysis; natural products; polyphenols
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MDPI and ACS Style

Lu, X.; Saeed, M.E.M.; Hegazy, M.-E.F.; Kampf, C.J.; Efferth, T. Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells. Biomolecules 2020, 10, 1000. https://doi.org/10.3390/biom10071000

AMA Style

Lu X, Saeed MEM, Hegazy M-EF, Kampf CJ, Efferth T. Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells. Biomolecules. 2020; 10(7):1000. https://doi.org/10.3390/biom10071000

Chicago/Turabian Style

Lu, Xiaohua; Saeed, Mohamed E.M.; Hegazy, Mohamed-Elamir F.; Kampf, Christopher J.; Efferth, Thomas. 2020. "Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells" Biomolecules 10, no. 7: 1000. https://doi.org/10.3390/biom10071000

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