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Open AccessArticle

8-Hydroxyquinoline-2-Carboxylic Acid as Possible Molybdophore: A Multi-Technique Approach to Define Its Chemical Speciation, Coordination and Sequestering Ability in Aqueous Solution

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Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, Italy
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Scuola Normale Superiore, Palazzo della Carovana, Classe di Scienze Matematiche e Naturali, Piazza dei Cavalieri, 7, 56126 Pisa, Italy
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Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Viale Consolare Valeria s.n., 98125 Messina, Italy
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Dipartimento di Fisica e Chimica Emilio Segrè, Università degli Studi di Palermo, Viale delle Scienze, Ed. 17., 90128 Palermo, Italy
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Department of Analytical Chemistry, Faculty of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland
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Chromaleont s.r.l., c/o Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy
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Facoltà Dipartimentale di Scienze e Tecnologie per l’Uomo e l’Ambiente, Università Campus Bio-Medico di Roma, 00128 Roma, Italy
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BeSep s.r.l., c/o Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy
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Institut für Anorganische und Analytische Chemie, Friedrich-Schiller-Universität Jena, Humboldtstr 8, 07743 Jena, Germany
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Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 930; https://doi.org/10.3390/biom10060930
Received: 29 May 2020 / Accepted: 17 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Toxic and Essential Metals in Human Health and Disease)
8-hydroxyquinoline-2-carboxylic acid (8-HQA) has been found in high concentrations (0.5–5.0 mmol·dm−3) in the gut of Noctuid larvae (and in a few other lepidopterans), in which it is proposed to act as a siderophore. Since it is known that many natural siderophores are also involved in the uptake and metabolism of other essential elements than iron, this study reports some results on the investigation of 8-HQA interactions with molybdate (MoO42−, i.e., the main molybdenum form in aqueous environments), in order to understand the possible role of this ligand as molybdophore. A multi-technique approach has been adopted, in order to derive a comprehensive set of information necessary to assess the chemical speciation of the 8-HQA/MoO42− system, as well as the coordination behavior and the sequestering ability of 8-HQA towards molybdate. Chemical speciation studies have been performed in KCl(aq) at I = 0.2 mol·dm−3 and T = 298.15 K by ISE-H+ (glass electrode) potentiometric and UV/Vis spectrophotometric titrations. CV (Cyclic Voltammetry), DP-ASV (Differential Pulse-Anodic Stripping Voltammetry), ESI-MS experiments and quantum mechanical calculations have been also performed to derive information about the nature and possible structure of species formed. These results are also compared with those reported for the 8-HQA/Fe3+ system in terms of chemical speciation and sequestering ability of 8-HQA. View Full-Text
Keywords: chemical speciation; metal complexes; metallophores; molybdate; natural chelants; sequestration; stability constants chemical speciation; metal complexes; metallophores; molybdate; natural chelants; sequestration; stability constants
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MDPI and ACS Style

Arena, K.; Brancato, G.; Cacciola, F.; Crea, F.; Cataldo, S.; De Stefano, C.; Gama, S.; Lando, G.; Milea, D.; Mondello, L.; Pettignano, A.; Plass, W.; Sammartano, S. 8-Hydroxyquinoline-2-Carboxylic Acid as Possible Molybdophore: A Multi-Technique Approach to Define Its Chemical Speciation, Coordination and Sequestering Ability in Aqueous Solution. Biomolecules 2020, 10, 930.

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