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Review

A Day in the Life of the Exon Junction Complex

Institute for Genetics, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany
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Biomolecules 2020, 10(6), 866; https://doi.org/10.3390/biom10060866
Received: 1 May 2020 / Revised: 29 May 2020 / Accepted: 2 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Ribonucleoprotein Particles (RNPs): From Structure to Function)
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC’s core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC’s life cycle. View Full-Text
Keywords: mRNA; gene regulation; RNA processing; RNA-binding protein mRNA; gene regulation; RNA processing; RNA-binding protein
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MDPI and ACS Style

Schlautmann, L.P.; Gehring, N.H. A Day in the Life of the Exon Junction Complex. Biomolecules 2020, 10, 866. https://doi.org/10.3390/biom10060866

AMA Style

Schlautmann LP, Gehring NH. A Day in the Life of the Exon Junction Complex. Biomolecules. 2020; 10(6):866. https://doi.org/10.3390/biom10060866

Chicago/Turabian Style

Schlautmann, Lena P.; Gehring, Niels H. 2020. "A Day in the Life of the Exon Junction Complex" Biomolecules 10, no. 6: 866. https://doi.org/10.3390/biom10060866

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