Next Article in Journal
Anti-Apoptotic and Antioxidant Effects of 3-Epi-Iso-Seco-Tanapartholide Isolated from Artemisia argyi against Iodixanol-Induced Kidney Epithelial Cell Death
Next Article in Special Issue
Crystal Structure of a Variant PAM2 Motif of LARP4B Bound to the MLLE Domain of PABPC1
Previous Article in Journal
Comparative Genomics Determines Strain-Dependent Secondary Metabolite Production in Streptomyces venezuelae Strains
Previous Article in Special Issue
snoRNPs: Functions in Ribosome Biogenesis

A Day in the Life of the Exon Junction Complex

Institute for Genetics, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 866;
Received: 1 May 2020 / Revised: 29 May 2020 / Accepted: 2 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Ribonucleoprotein Particles (RNPs): From Structure to Function)
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC’s core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC’s life cycle. View Full-Text
Keywords: mRNA; gene regulation; RNA processing; RNA-binding protein mRNA; gene regulation; RNA processing; RNA-binding protein
Show Figures

Figure 1

MDPI and ACS Style

Schlautmann, L.P.; Gehring, N.H. A Day in the Life of the Exon Junction Complex. Biomolecules 2020, 10, 866.

AMA Style

Schlautmann LP, Gehring NH. A Day in the Life of the Exon Junction Complex. Biomolecules. 2020; 10(6):866.

Chicago/Turabian Style

Schlautmann, Lena P., and Niels H. Gehring. 2020. "A Day in the Life of the Exon Junction Complex" Biomolecules 10, no. 6: 866.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop