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snoRNPs: Functions in Ribosome Biogenesis

1
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02115, USA
2
The Genome Science Institute, Boston University School of Medicine, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(5), 783; https://doi.org/10.3390/biom10050783
Received: 20 April 2020 / Revised: 10 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Ribonucleoprotein Particles (RNPs): From Structure to Function)
Ribosomes are perhaps the most critical macromolecular machine as they are tasked with carrying out protein synthesis in cells. They are incredibly complex structures composed of protein components and heavily chemically modified RNAs. The task of assembling mature ribosomes from their component parts consumes a massive amount of energy and requires greater than 200 assembly factors. Among the most critical of these are small nucleolar ribonucleoproteins (snoRNPs). These are small RNAs complexed with diverse sets of proteins. As suggested by their name, they localize to the nucleolus, the site of ribosome biogenesis. There, they facilitate multiple roles in ribosomes biogenesis, such as pseudouridylation and 2′-O-methylation of ribosomal (r)RNA, guiding pre-rRNA processing, and acting as molecular chaperones. Here, we reviewed their activity in promoting the assembly of ribosomes in eukaryotes with regards to chemical modification and pre-rRNA processing. View Full-Text
Keywords: snoRNA; snoRNP; ribosome biogenesis; pseudouridylation; 2′-O-methylation; RNA processing snoRNA; snoRNP; ribosome biogenesis; pseudouridylation; 2′-O-methylation; RNA processing
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MDPI and ACS Style

Ojha, S.; Malla, S.; Lyons, S.M. snoRNPs: Functions in Ribosome Biogenesis. Biomolecules 2020, 10, 783. https://doi.org/10.3390/biom10050783

AMA Style

Ojha S, Malla S, Lyons SM. snoRNPs: Functions in Ribosome Biogenesis. Biomolecules. 2020; 10(5):783. https://doi.org/10.3390/biom10050783

Chicago/Turabian Style

Ojha, Sandeep; Malla, Sulochan; Lyons, Shawn M. 2020. "snoRNPs: Functions in Ribosome Biogenesis" Biomolecules 10, no. 5: 783. https://doi.org/10.3390/biom10050783

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