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Open AccessArticle

Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras

1
Drug Discovery and Development Division, Patanjali Research Institute, Haridwar 249 401, India
2
Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Haridwar 249 401, India
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(4), 600; https://doi.org/10.3390/biom10040600
Received: 29 February 2020 / Revised: 6 April 2020 / Accepted: 6 April 2020 / Published: 13 April 2020
(This article belongs to the Special Issue Zebrafish: A Model for the Study of Human Diseases)
Zebrafish is an elegant vertebrate employed to model the pathological etiologies of human maladies such as cardiac diseases. Persistent physiological stresses can induce abnormalities in heart functions such as cardiac hypertrophy (CH), which can lead to morbidity and mortality. In the present study, using zebrafish as a study model, efficacy of the traditional Indian Ayurveda medicine “Yogendra Ras” (YDR) was validated in ameliorating drug-induced cardiac hypertrophy. YDR was prepared using traditionally described methods and composed of nano- and micron-sized metal particles. Elemental composition analysis of YDR showed the presence of mainly Au, Sn, and Hg. Cardiac hypertrophy was induced in the zebrafish following a pretreatment with erythromycin (ERY), and the onset and reconciliation of disease by YDR were determined using a treadmill electrocardiogram, heart anatomy analysis, C-reactive protein release, and platelet aggregation time-analysis. YDR treatment of CH-induced zebrafish showed comparable results with the Standard-of-care drug, verapamil, tested in parallel. Under in-vitro conditions, treatment of isoproterenol (ISP)-stimulated murine cardiomyocytes (H9C2) with YDR resulted in the suppression of drug-stimulated biomarkers of oxidative stress: COX-2, NOX-2, NOX-4, ANF, troponin-I, -T, and cardiolipin. Taken together, zebrafish showed a strong disposition as a model for studying the efficacy of Ayurvedic medicines towards drug-induced cardiopathies. YDR provided strong evidence for its capability in modulating drug-induced CH through the restoration of redox homeostasis and exhibited potential as a viable complementary therapy.
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Keywords: Ayurveda; cardiac hypertrophy; zebrafish model; H9C2; erythromycin; isoproterenol; oxidative stress; Yogendra Ras; biomarkers Ayurveda; cardiac hypertrophy; zebrafish model; H9C2; erythromycin; isoproterenol; oxidative stress; Yogendra Ras; biomarkers
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MDPI and ACS Style

Balkrishna, A.; Rustagi, Y.; Bhattacharya, K.; Varshney, A. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules 2020, 10, 600. https://doi.org/10.3390/biom10040600

AMA Style

Balkrishna A, Rustagi Y, Bhattacharya K, Varshney A. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules. 2020; 10(4):600. https://doi.org/10.3390/biom10040600

Chicago/Turabian Style

Balkrishna, Acharya; Rustagi, Yashika; Bhattacharya, Kunal; Varshney, Anurag. 2020. "Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras" Biomolecules 10, no. 4: 600. https://doi.org/10.3390/biom10040600

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