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Open AccessReview

The Role of Reactive Oxygen Species in Arsenic Toxicity

1
Experimental Teaching Center, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China
2
Program of Environmental Toxicology, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 240; https://doi.org/10.3390/biom10020240
Received: 13 January 2020 / Revised: 28 January 2020 / Accepted: 29 January 2020 / Published: 5 February 2020
Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants. View Full-Text
Keywords: antioxidants; arsenic; Nrf2; ROS; signaling pathway antioxidants; arsenic; Nrf2; ROS; signaling pathway
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MDPI and ACS Style

Hu, Y.; Li, J.; Lou, B.; Wu, R.; Wang, G.; Lu, C.; Wang, H.; Pi, J.; Xu, Y. The Role of Reactive Oxygen Species in Arsenic Toxicity. Biomolecules 2020, 10, 240.

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