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Open AccessArticle

Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants

1
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
2
Department of Cardiovascular Surgery, Asia University Hospital, Taichung 40201, Taiwan
3
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
4
Office of Physical Education, Chung Yuan Christian University, Taoyuan 32023, Taiwan
5
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
6
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 244; https://doi.org/10.3390/biom10020244
Received: 20 December 2019 / Revised: 25 January 2020 / Accepted: 3 February 2020 / Published: 5 February 2020
(This article belongs to the Section Biomacromolecules)
Hyperlipidemia is one of the strong risk factors for ischemic heart disease. Using the Taiwan Biobank (TWB) database, we evaluated the risk of hyperlipidemia and its interaction with sex and rs688 polymorphism on the low-density lipoprotein receptor (LDLR) gene. Data collection in the biobank started in 2008 and is ongoing. Data analysis was performed on the participants’ data collected between 2008 and 2015. In general, 27.92% of the 9237 female participants and 32.65% of the 8690 male participants were identified with hyperlipidemia. Compared to the C/C genotype, C/T and T/T genotypes were not significant risk factors for hyperlipidemia (OR = 1.061, CI: 0.976–1.153 for C/T and OR = 1.052, CI: 0.845–1.309 for T/T genotype) in the general model. However, there was a significant interaction between sex and rs6888 on hyperlipidemia risk (p-interaction = 0.0321). With the male sex/CC genotype being the reference group, only the female sex/CT and T/T genotypes were closely associated with hyperlipidemia, with respective ORs of 1.153 (CI: 1.014–1.311) and 1.423 (CI: 1.056–1.917). Our data indicate that rs688 C/T and T/T genotypes may be associated with increased risk of hyperlipidemia in Taiwanese women. These findings may be relevant in lipid-modification therapy.
Keywords: hyperlipidemia; sex; biobank; polymorphism hyperlipidemia; sex; biobank; polymorphism
MDPI and ACS Style

Liu, Y.-T.; Nfor, O.N.; Wang, L.; Hsu, S.-Y.; Lung, C.-C.; Tantoh, D.M.; Wu, M.-C.; Chang, H.-R.; Liaw, Y.-P. Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants. Biomolecules 2020, 10, 244.

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