Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants

Liu, Yin-Tso; Nfor, Oswald Ndi; Wang, Lee; Hsu, Shu-Yi; Lung, Chia-Chi; Tantoh, Disline Manli; Wu, Min-Chen; Chang, Horng-Rong; Liaw, Yung-Po

doi:10.3390/biom10020244

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants

^1,2,

³,

³,

³,

³,

⁴,

^1,5,* and

^3,6,*

School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

Department of Cardiovascular Surgery, Asia University Hospital, Taichung 40201, Taiwan

Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan

⁴

Office of Physical Education, Chung Yuan Christian University, Taoyuan 32023, Taiwan

⁵

Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

⁶

Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan

Authors to whom correspondence should be addressed.

Biomolecules 2020, 10(2), 244; https://doi.org/10.3390/biom10020244

Received: 20 December 2019 / Revised: 25 January 2020 / Accepted: 3 February 2020 / Published: 5 February 2020

View Full-Text Download PDF Citation Export

Abstract

Hyperlipidemia is one of the strong risk factors for ischemic heart disease. Using the Taiwan Biobank (TWB) database, we evaluated the risk of hyperlipidemia and its interaction with sex and rs688 polymorphism on the low-density lipoprotein receptor (LDLR) gene. Data collection in the biobank started in 2008 and is ongoing. Data analysis was performed on the participants’ data collected between 2008 and 2015. In general, 27.92% of the 9237 female participants and 32.65% of the 8690 male participants were identified with hyperlipidemia. Compared to the C/C genotype, C/T and T/T genotypes were not significant risk factors for hyperlipidemia (OR = 1.061, CI: 0.976–1.153 for C/T and OR = 1.052, CI: 0.845–1.309 for T/T genotype) in the general model. However, there was a significant interaction between sex and rs6888 on hyperlipidemia risk (p-interaction = 0.0321). With the male sex/CC genotype being the reference group, only the female sex/CT and T/T genotypes were closely associated with hyperlipidemia, with respective ORs of 1.153 (CI: 1.014–1.311) and 1.423 (CI: 1.056–1.917). Our data indicate that rs688 C/T and T/T genotypes may be associated with increased risk of hyperlipidemia in Taiwanese women. These findings may be relevant in lipid-modification therapy. View Full-Text

Keywords: hyperlipidemia; sex; biobank; polymorphism

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Share and Cite

MDPI and ACS Style

Liu, Y.-T.; Nfor, O.N.; Wang, L.; Hsu, S.-Y.; Lung, C.-C.; Tantoh, D.M.; Wu, M.-C.; Chang, H.-R.; Liaw, Y.-P. Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants. Biomolecules 2020, 10, 244. https://doi.org/10.3390/biom10020244

AMA Style

Liu Y-T, Nfor ON, Wang L, Hsu S-Y, Lung C-C, Tantoh DM, Wu M-C, Chang H-R, Liaw Y-P. Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants. Biomolecules. 2020; 10(2):244. https://doi.org/10.3390/biom10020244

Chicago/Turabian Style

Liu, Yin-Tso, Oswald N. Nfor, Lee Wang, Shu-Yi Hsu, Chia-Chi Lung, Disline M. Tantoh, Min-Chen Wu, Horng-Rong Chang, and Yung-Po Liaw. 2020. "Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants" Biomolecules 10, no. 2: 244. https://doi.org/10.3390/biom10020244

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI