DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy
1
Faculty of Chemical-Biological Sciences, PhD program in Biomedical Sciences, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39087, Mexico
2
Faculty of Chemical-Biological Sciences, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39087, Mexico
3
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(11), 1479; https://doi.org/10.3390/biom10111479
Received: 16 September 2020 / Revised: 10 October 2020 / Accepted: 21 October 2020 / Published: 24 October 2020
(This article belongs to the Special Issue Pathogenesis of Arthritis)
Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a role in gut dysbiosis, which indicates that the microbiota variability could modify the employment of direct and indirect mechanisms in the response to treatment. The main objective of this review was to understand the gut microbiota bacterial variability in patients with RA, pre and post-treatment with DMARDs, and to identify the possible mechanisms through which microbiota can regulate the response to pharmacological therapy.
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Keywords:
DMARDs; gut microbiota; dysbiosis; rheumatoid arthritis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Zaragoza-García, O.; Castro-Alarcón, N.; Pérez-Rubio, G.; Guzmán-Guzmán, I.P. DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy. Biomolecules 2020, 10, 1479. https://doi.org/10.3390/biom10111479
AMA Style
Zaragoza-García O, Castro-Alarcón N, Pérez-Rubio G, Guzmán-Guzmán IP. DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy. Biomolecules. 2020; 10(11):1479. https://doi.org/10.3390/biom10111479
Chicago/Turabian StyleZaragoza-García, Oscar; Castro-Alarcón, Natividad; Pérez-Rubio, Gloria; Guzmán-Guzmán, Iris P. 2020. "DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy" Biomolecules 10, no. 11: 1479. https://doi.org/10.3390/biom10111479
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