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Review

Microglia in Alzheimer’s Disease in the Context of Tau Pathology

1
Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), 1 Nicolás Cabrera, 28049 Madrid, Spain
2
Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), 5 Valderrebollo, 28031 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(10), 1439; https://doi.org/10.3390/biom10101439
Received: 18 September 2020 / Revised: 9 October 2020 / Accepted: 10 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Microglia in Neurodegeneration)
Microglia are the cells that comprise the innate immune system in the brain. First described more than a century ago, these cells were initially assigned a secondary role in the central nervous system (CNS) with respect to the protagonists, neurons. However, the latest advances have revealed the complexity and importance of microglia in neurodegenerative conditions such as Alzheimer’s disease (AD), the most common form of dementia associated with aging. This pathology is characterized by the accumulation of amyloid-β peptide (Aβ), which forms senile plaques in the neocortex, as well as by the aggregation of hyperphosphorylated tau protein, a process that leads to the development of neurofibrillary tangles (NFTs). Over the past few years, efforts have been focused on studying the interaction between Aβ and microglia, together with the ability of the latter to decrease the levels of this peptide. Given that most clinical trials following this strategy have failed, current endeavors focus on deciphering the molecular mechanisms that trigger the tau-induced inflammatory response of microglia. In this review, we summarize the most recent studies on the physiological and pathological functions of tau protein and microglia. In addition, we analyze the impact of microglial AD-risk genes (APOE, TREM2, and CD33) in tau pathology, and we discuss the role of extracellular soluble tau in neuroinflammation. View Full-Text
Keywords: Alzheimer’s disease; tauopathies; tau; Aβ; microglia; neuroinflammation; ApoE; TREM2; CD33; CX3CR1 Alzheimer’s disease; tauopathies; tau; ; microglia; neuroinflammation; ApoE; TREM2; CD33; CX3CR1
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MDPI and ACS Style

Perea, J.R.; Bolós, M.; Avila, J. Microglia in Alzheimer’s Disease in the Context of Tau Pathology. Biomolecules 2020, 10, 1439. https://doi.org/10.3390/biom10101439

AMA Style

Perea JR, Bolós M, Avila J. Microglia in Alzheimer’s Disease in the Context of Tau Pathology. Biomolecules. 2020; 10(10):1439. https://doi.org/10.3390/biom10101439

Chicago/Turabian Style

Perea, Juan R., Marta Bolós, and Jesús Avila. 2020. "Microglia in Alzheimer’s Disease in the Context of Tau Pathology" Biomolecules 10, no. 10: 1439. https://doi.org/10.3390/biom10101439

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