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The Morphology and Phenotype of Monocyte-Macrophages When Cultured on Bionanofilms Substrates with Different Surface Relief Profiles

1
Siberian Federal University, 79, Svobodnyav, 660041 Krasnoyarsk, Russia
2
L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, 50/38 Akademgorodok, 660036 Krasnoyarsk, Russia
3
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, 50 Akademgorodok, 660036 Krasnoyarsk, Russia
4
Federal Center for Cardiovascular Surgery, 45 Karaulnaya, 660020 Krasnoyarsk, Russia
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 65; https://doi.org/10.3390/biom10010065
Received: 9 November 2019 / Revised: 24 December 2019 / Accepted: 26 December 2019 / Published: 30 December 2019
(This article belongs to the Section Biological Materials)
The effect of surface relief profiles of alkanoate-based bionanofilms to the monocyte-macrophages (MN-MPhs) from peripheral blood of patients with atherosclerosis was studied in vitro. Patients were subjected to coronary stenting. Cell morphology and phenotype (expression of CD antigens, levels of production of marker cytokines) in vitro were analyzed before and after the installation of stents. It was shown, that the mean square roughness (Rq) of the bionanofilms determined the variability of cell morphology, CD antigens spectraand activity of production interleukins-6 and -10. Also, it was revealed, that the “activity” of the surface topography of biopolymer substrates depends on the functional state of MNs, isolated in different time points: Before and after stenting the ratios of cell morphotypes and production of cytokines in MN-MPhs differed significantly. View Full-Text
Keywords: atherosclerosis; monocyte-macrophages morphology; alkanoate-based bionanofilms; surface relief atherosclerosis; monocyte-macrophages morphology; alkanoate-based bionanofilms; surface relief
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Menzyanova, N.G.; Pyatina, S.A.; Shabanov, A.V.; Nemtsev, I.V.; Stolyarov, D.P.; Dryganov, D.B.; Sakhnov, E.V.; Shishatskaya, E.I. The Morphology and Phenotype of Monocyte-Macrophages When Cultured on Bionanofilms Substrates with Different Surface Relief Profiles. Biomolecules 2020, 10, 65.

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