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Open AccessFeature PaperArticle

Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration

Biomaterials for Regenerative Therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain
CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain
Tissue Engineering Laboratory, IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain
Department of Materials Science and Metallurgical Engineering, EEBE campus, Technical University of Catalonia (UPC), 08019 Barcelona, Spain
Hebe Biolab S.L., C/Can Castellvi 27, 08017 Barcelona, Spain
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 52;
Received: 28 October 2019 / Revised: 19 December 2019 / Accepted: 26 December 2019 / Published: 28 December 2019
(This article belongs to the Special Issue Self-Assembling Peptides)
Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe pain, loss of mobility and consequently, a loss of quality of life. Current strategies in medicine are focused on the partial or total replacement of affected joints, physiotherapy and analgesics that do not address the underlying pathology. In an attempt to find an alternative therapy to restore or repair articular cartilage functions, the use of bioengineered tissues is proposed. In this study we present a three-dimensional (3D) bioengineered platform combining a 3D printed polycaprolactone (PCL) macrostructure with RAD16-I, a soft nanofibrous self-assembling peptide, as a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. This 3D bioengineered platform allows for long-term hMSC culture resulting in chondrogenic differentiation and has mechanical properties resembling native articular cartilage. These promising results suggest that this approach could be potentially used in articular cartilage repair and regeneration. View Full-Text
Keywords: polycaprolactone; 3D printing; RAD16-I self-assembling peptide; chondrogenic differentiation polycaprolactone; 3D printing; RAD16-I self-assembling peptide; chondrogenic differentiation
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MDPI and ACS Style

Rubí-Sans, G.; Recha-Sancho, L.; Pérez-Amodio, S.; Mateos-Timoneda, M.Á.; Semino, C.E.; Engel, E. Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration. Biomolecules 2020, 10, 52.

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