Next Article in Journal
Synthesis and Application of a Thermoplastic Plate of Poly(lactide-ε-caprolactone) for Radiation Therapy
Next Article in Special Issue
Kernel Differential Subgraph Analysis to Reveal the Key Period Affecting Glioblastoma
Previous Article in Journal
Elicitation of Novel Trichogenic-Lipid Nanoemulsion Signaling Resistance Against Pearl Millet Downy Mildew Disease
Previous Article in Special Issue
Artificial Neural Network (ANN) as a Tool to Reduce Human-Animal Interaction Improves Senegalese Sole Production
Open AccessReview

Graph Theory-Based Sequence Descriptors as Remote Homology Predictors

CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n 4450-208 Porto, Portugal
Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal
Departamento de Ciencia de la Computación. Universidad Central ¨Marta Abreu¨ de Las Villas (UCLV), Santa Clara 54830, Cuba
Centro de Bioactivos Químicos (CBQ), Universidad Central ¨Marta Abreu¨ de Las Villas (UCLV), Santa Clara 54830, Cuba
Programa de Doctorado en Fisicoquímica Molecular, Facultad de Ciencias Exactas, Universidad Andrés Bello, Av. República 239, Santiago 8370146, Chile
EpiDisease S.L. Spin-Off of Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 46980 Valencia, Spain
Laboratorio de Biotecnología Aplicada S. de R.L. de C.V., GRECA Inc., Carretera La Piedad-Carapán, km 3.5, La Piedad, Michoacán 59300, Mexico
Tecnológico Nacional de México, Instituto Tecnológico de la Piedad, Av. Ricardo Guzmán Romero, Santa Fe, La Piedad de Cavadas, Michoacán 59370, Mexico
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 26;
Received: 19 November 2019 / Revised: 16 December 2019 / Accepted: 18 December 2019 / Published: 23 December 2019
Alignment-free (AF) methodologies have increased in popularity in the last decades as alternative tools to alignment-based (AB) algorithms for performing comparative sequence analyses. They have been especially useful to detect remote homologs within the twilight zone of highly diverse gene/protein families and superfamilies. The most popular alignment-free methodologies, as well as their applications to classification problems, have been described in previous reviews. Despite a new set of graph theory-derived sequence/structural descriptors that have been gaining relevance in the detection of remote homology, they have been omitted as AF predictors when the topic is addressed. Here, we first go over the most popular AF approaches used for detecting homology signals within the twilight zone and then bring out the state-of-the-art tools encoding graph theory-derived sequence/structure descriptors and their success for identifying remote homologs. We also highlight the tendency of integrating AF features/measures with the AB ones, either into the same prediction model or by assembling the predictions from different algorithms using voting/weighting strategies, for improving the detection of remote signals. Lastly, we briefly discuss the efforts made to scale up AB and AF features/measures for the comparison of multiple genomes and proteomes. Alongside the achieved experiences in remote homology detection by both the most popular AF tools and other less known ones, we provide our own using the graphical–numerical methodologies, MARCH-INSIDE, TI2BioP, and ProtDCal. We also present a new Python-based tool (SeqDivA) with a friendly graphical user interface (GUI) for delimiting the twilight zone by using several similar criteria. View Full-Text
Keywords: QSAR; topological indices; alignment-free; bioinformatics; big data QSAR; topological indices; alignment-free; bioinformatics; big data
Show Figures

Graphical abstract

MDPI and ACS Style

Agüero-Chapin, G.; Galpert, D.; Molina-Ruiz, R.; Ancede-Gallardo, E.; Pérez-Machado, G.; De la Riva, G.A.; Antunes, A. Graph Theory-Based Sequence Descriptors as Remote Homology Predictors. Biomolecules 2020, 10, 26.

AMA Style

Agüero-Chapin G, Galpert D, Molina-Ruiz R, Ancede-Gallardo E, Pérez-Machado G, De la Riva GA, Antunes A. Graph Theory-Based Sequence Descriptors as Remote Homology Predictors. Biomolecules. 2020; 10(1):26.

Chicago/Turabian Style

Agüero-Chapin, Guillermin; Galpert, Deborah; Molina-Ruiz, Reinaldo; Ancede-Gallardo, Evys; Pérez-Machado, Gisselle; De la Riva, Gustavo A.; Antunes, Agostinho. 2020. "Graph Theory-Based Sequence Descriptors as Remote Homology Predictors" Biomolecules 10, no. 1: 26.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop