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Open AccessArticle

Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom

1
Plants and Environmental Sciences, the Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel
2
Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
3
Metabomed Ltd., Yavne 81220, Israel
4
The Yigal Allon Kinneret Limnological Laboratory, Israel Oceanographic and Limnological Research, Migdal 14950, Israel
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(6), 110; https://doi.org/10.3390/metabo9060110
Received: 13 May 2019 / Revised: 2 June 2019 / Accepted: 6 June 2019 / Published: 9 June 2019
(This article belongs to the Special Issue Metabolomics in Chemical Ecology)
Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below. View Full-Text
Keywords: Aeromonas veronii; Microcystis aeruginosa; secondary metabolites Aeromonas veronii; Microcystis aeruginosa; secondary metabolites
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MDPI and ACS Style

Weiss, G.; Kovalerchick, D.; Murik, O.; Sukenik, A.; Kaplan, A.; Carmeli, S. Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom. Metabolites 2019, 9, 110.

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