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Volume 15
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10.3390/metabo15010027
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Article

Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI+-MS

by
Alexandra Traila
1,2,
Marius Craina
3,
Carmen Socaciu
4,
Andreea Iulia Socaciu
5,
Diana Nitusca
6,7,* and
Catalin Marian
6,7
1
Doctoral School, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania
2
Obstetrics and Gynecology Clinic, Emergency Municipal Clinical Hospital, 300172 Timisoara, Romania
3
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania
4
Biodiatech, Research Center for Applied Biotechnology in Diagnosis and Molecular Therapy, 400478 Cluj-Napoca, Romania
5
Department of Occupational Health, Iuliu Hateganu University of Medicine and Pharmacy, Str. Victor Babes Nr. 8, 400347 Cluj-Napoca, Romania
6
Department of Biochemistry and Pharmacology, Victor Babes University of Medicine and Pharmacy, Pta Eftimie Murgu Nr. 2, 300041 Timisoara, Romania
7
Center for Complex Networks Science, Victor Babes University of Medicine and Pharmacy, Pta Eftimie Murgu Nr. 2, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Metabolites 2025, 15(1), 27; https://doi.org/10.3390/metabo15010027
Submission received: 3 December 2024 / Revised: 31 December 2024 / Accepted: 6 January 2025 / Published: 8 January 2025
(This article belongs to the Special Issue The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment)
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Abstract

Background: Pregnancy induces significant physiological and metabolic changes in the mother to support fetal growth and prepare for childbirth. These adaptations impact various systems, including immune tolerance, metabolism, and endocrine function. While metabolomics has been utilized to study pregnancy-related metabolic changes, comprehensive comparisons between pregnant and non-pregnant states, particularly using ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS), remain limited. Methods: This study aimed to explore the dynamic, longitudinal metabolic shifts during pregnancy by profiling plasma samples from 65 pregnant women across three time points (6–14 weeks, 14–22 weeks, and >24 weeks) and 42 postpartum women. Lipidomics was prioritized, and a solvent mixture was employed to enhance lipid extraction, using UHPLC-QTOF-ESI+-MS. Results: A total of 290 metabolites were identified and analyzed. Our results revealed significant metabolic differences between pregnant and postpartum women, with lipid molecules such as estrogen derivatives, fatty acids, and ceramides showing strong potential as biomarkers. Further biomarker analysis highlighted distinct metabolic signatures between early and late pregnancy stages, particularly in lipid metabolism (with AUC values > 0.8). Conclusions: These findings contribute to a deeper understanding of pregnancy-related metabolic changes and may offer insights into maternal and neonatal health outcomes.
Keywords: lipidomics; biomarkers; metabolomics; pregnancy; postpartum lipidomics; biomarkers; metabolomics; pregnancy; postpartum

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MDPI and ACS Style

Traila, A.; Craina, M.; Socaciu, C.; Socaciu, A.I.; Nitusca, D.; Marian, C. Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI+-MS. Metabolites 2025, 15, 27. https://doi.org/10.3390/metabo15010027

AMA Style

Traila A, Craina M, Socaciu C, Socaciu AI, Nitusca D, Marian C. Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI+-MS. Metabolites. 2025; 15(1):27. https://doi.org/10.3390/metabo15010027

Chicago/Turabian Style

Traila, Alexandra, Marius Craina, Carmen Socaciu, Andreea Iulia Socaciu, Diana Nitusca, and Catalin Marian. 2025. "Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI+-MS" Metabolites 15, no. 1: 27. https://doi.org/10.3390/metabo15010027

APA Style

Traila, A., Craina, M., Socaciu, C., Socaciu, A. I., Nitusca, D., & Marian, C. (2025). Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI+-MS. Metabolites, 15(1), 27. https://doi.org/10.3390/metabo15010027

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