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Metabolites
Volume 14
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10.3390/metabo14080458
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Article

Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model

by
Adam Varga
,
Adam Attila Matrai
,
Barbara Bedocs-Barath
,
Laszlo Adam Fazekas
,
Felipe Salignac Brasil
,
Aashna Mehta
,
Erzsebet Vanyolos
,
Adam Deak
,
Tamas Lesznyak
,
Katalin Peto
and
Norbert Nemeth
*
Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4032 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(8), 458; https://doi.org/10.3390/metabo14080458
Submission received: 18 July 2024 / Revised: 15 August 2024 / Accepted: 17 August 2024 / Published: 18 August 2024
(This article belongs to the Special Issue Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery)
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Abstract

Hemorheological factors may show arterio-venous differences. Alterations in acid-base and metabolic parameters may also influence these factors. However, little is known about changes in micro-rheological parameters during abdominal surgery, influencing splanchnic circulation. In anesthetized pigs, the external jugular vein, femoral artery and vein were cannulated unilaterally, and paramedian laparotomy was performed. In the anastomosis group, after resecting a bowel segment, end-to-end jejuno-jejunostomy was completed. Blood samples (from cannulas and by puncturing the portal vein) were taken before and after the intervention. Hematological, acid-base and blood gas parameters, metabolites, red blood cell (RBC) deformability and aggregation were determined. The highest hematocrit was found in portal blood, increasing further by the end of operation. A significant pH decrease was seen, and portal blood showed the highest lactate and creatinine concentration. The highest RBC aggregation values were found in arterial, the lowest in renal venous blood. The RBC aggregation increased with higher lactate concentration and lower pH. Osmotic gradient deformability declined, with the lowest values in portal and renal venous samples. In conclusion, micro-rheological parameters showed arterio-venous and porto-renal venous differences, influenced by oxygenation level, pH and lactate concentration. The intestinal anastomosis operation caused an immediate micro-rheological deterioration with portal venous dominancy in this experiment.
Keywords: hemorheology; microcirculation; intestinal anastomosis; red blood cell deformability; osmotic gradient ektacytometry; red blood cell aggregation hemorheology; microcirculation; intestinal anastomosis; red blood cell deformability; osmotic gradient ektacytometry; red blood cell aggregation

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MDPI and ACS Style

Varga, A.; Matrai, A.A.; Bedocs-Barath, B.; Fazekas, L.A.; Brasil, F.S.; Mehta, A.; Vanyolos, E.; Deak, A.; Lesznyak, T.; Peto, K.; et al. Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model. Metabolites 2024, 14, 458. https://doi.org/10.3390/metabo14080458

AMA Style

Varga A, Matrai AA, Bedocs-Barath B, Fazekas LA, Brasil FS, Mehta A, Vanyolos E, Deak A, Lesznyak T, Peto K, et al. Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model. Metabolites. 2024; 14(8):458. https://doi.org/10.3390/metabo14080458

Chicago/Turabian Style

Varga, Adam, Adam Attila Matrai, Barbara Bedocs-Barath, Laszlo Adam Fazekas, Felipe Salignac Brasil, Aashna Mehta, Erzsebet Vanyolos, Adam Deak, Tamas Lesznyak, Katalin Peto, and et al. 2024. "Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model" Metabolites 14, no. 8: 458. https://doi.org/10.3390/metabo14080458

APA Style

Varga, A., Matrai, A. A., Bedocs-Barath, B., Fazekas, L. A., Brasil, F. S., Mehta, A., Vanyolos, E., Deak, A., Lesznyak, T., Peto, K., & Nemeth, N. (2024). Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model. Metabolites, 14(8), 458. https://doi.org/10.3390/metabo14080458

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