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Metabolites
Volume 14
Issue 4
10.3390/metabo14040185
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Brief Report

Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls

by
Ondřej Kučerka
1,2,
Marie Blahutová
3,
Vít Kosek
4,
Petra Mináriková
1,
Jan M. Horáček
2,
Petr Urbánek
1 and
Martin Malý
1,*
1
Department of Medicine, First Faculty of Medicine, Charles University and Military University Hospital Prague, 169 02 Prague, Czech Republic
2
Department of Military Internal Medicine and Military Hygiene, Military Faculty of Medicine, University of Defence, 500 02 Hradec Kralove, Czech Republic
3
Department of Clinical Biochemistry, Military University Hospital, 169 02 Prague, Czech Republic
4
Department of Food Chemistry and Analysis, University of Chemistry and Technology, 160 00 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(4), 185; https://doi.org/10.3390/metabo14040185
Submission received: 12 February 2024 / Revised: 8 March 2024 / Accepted: 21 March 2024 / Published: 25 March 2024
(This article belongs to the Special Issue Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery)
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Abstract

Inflammatory bowel disease, encompassing Crohn’s disease and ulcerative colitis, is a persistent immune-mediated inflammatory gastrointestinal disease. This study investigates the role of growth differentiation factor 15 in severe IBD cases, aiming to identify a reliable parameter to assess disease severity and monitor activity. We analyzed plasma samples from 100 patients undergoing biologic therapy for severe IBD and 50 control subjects. Our analysis included evaluations of GDF-15 levels, inflammatory markers, and clinical features. We employed statistical methods such as the Mann–Whitney U test, ANOVA, and Spearman’s correlation for an in-depth analysis. Our results demonstrated consistently higher GDF-15 levels in patients with both Crohn’s disease and ulcerative colitis compared to the control group, irrespective of the biologic treatment received. The correlation analysis indicated significant relationships between GDF-15 levels, patient age, fibrinogen, and IL-6 levels. This study positions GDF-15 as a promising biomarker for severe IBD, with notable correlations with age and inflammatory markers. These findings underscore GDF-15’s potential in enhancing disease monitoring and management strategies in an IBD context and encourage further research to clarify GDF-15’s role in the IBD pathophysiology.
Keywords: GDF-15; Inflammatory Bowel Disease; Crohn’s disease; ulcerative colitis GDF-15; Inflammatory Bowel Disease; Crohn’s disease; ulcerative colitis

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MDPI and ACS Style

Kučerka, O.; Blahutová, M.; Kosek, V.; Mináriková, P.; Horáček, J.M.; Urbánek, P.; Malý, M. Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls. Metabolites 2024, 14, 185. https://doi.org/10.3390/metabo14040185

AMA Style

Kučerka O, Blahutová M, Kosek V, Mináriková P, Horáček JM, Urbánek P, Malý M. Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls. Metabolites. 2024; 14(4):185. https://doi.org/10.3390/metabo14040185

Chicago/Turabian Style

Kučerka, Ondřej, Marie Blahutová, Vít Kosek, Petra Mináriková, Jan M. Horáček, Petr Urbánek, and Martin Malý. 2024. "Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls" Metabolites 14, no. 4: 185. https://doi.org/10.3390/metabo14040185

APA Style

Kučerka, O., Blahutová, M., Kosek, V., Mináriková, P., Horáček, J. M., Urbánek, P., & Malý, M. (2024). Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls. Metabolites, 14(4), 185. https://doi.org/10.3390/metabo14040185

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