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Metabolites
Volume 14
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10.3390/metabo14010071
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Review

Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD)

by
Antonella Mosca
1,*,
Melania Manco
2,
Maria Rita Braghini
3,
Stefano Cianfarani
4,5,6,
Giuseppe Maggiore
1,
Anna Alisi
3 and
Andrea Vania
7
1
Hepatology and Liver Transplant Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
2
Preventive and Predictive Medicine Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
3
Research Unit of Genetics of Complex Phenotypes, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
4
Endocrinology and Diabetes Unit, Bambino Gesù Pediatric Hospital, 00165 Rome, Italy
5
Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
6
Department of Women’s and Children’s Health, Karolinska Institutet, University Hospital, Solnavägen 1, Solna, 171 77 Stockholm, Sweden
7
Independent Researcher, 00162 Rome, Italy
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(1), 71; https://doi.org/10.3390/metabo14010071
Submission received: 5 December 2023 / Revised: 13 January 2024 / Accepted: 16 January 2024 / Published: 22 January 2024
(This article belongs to the Special Issue Diabetes, Obesity and Metabolic Disease)
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Abstract

Ecological theories suggest that environmental factors significantly influence obesity risk and related syndemic morbidities, including metabolically abnormal obesity associated with nonalcoholic fatty liver disease (MASLD). These factors encompass anthropogenic influences and endocrine-disrupting chemicals (EDCs), synergistically interacting to induce metabolic discrepancies, notably in early life, and disrupt metabolic processes in adulthood. This review focuses on endocrine disruptors affecting a child’s MASLD risk, independent of their role as obesogens and thus regardless of their impact on adipogenesis. The liver plays a pivotal role in metabolic and detoxification processes, where various lipophilic endocrine-disrupting molecules accumulate in fatty liver parenchyma, exacerbating inflammation and functioning as new anthropogenics that perpetuate chronic low-grade inflammation, especially insulin resistance, crucial in the pathogenesis of MASLD.
Keywords: MASLD; EDCs; insulin-resistance; children MASLD; EDCs; insulin-resistance; children

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MDPI and ACS Style

Mosca, A.; Manco, M.; Braghini, M.R.; Cianfarani, S.; Maggiore, G.; Alisi, A.; Vania, A. Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites 2024, 14, 71. https://doi.org/10.3390/metabo14010071

AMA Style

Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A. Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites. 2024; 14(1):71. https://doi.org/10.3390/metabo14010071

Chicago/Turabian Style

Mosca, Antonella, Melania Manco, Maria Rita Braghini, Stefano Cianfarani, Giuseppe Maggiore, Anna Alisi, and Andrea Vania. 2024. "Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD)" Metabolites 14, no. 1: 71. https://doi.org/10.3390/metabo14010071

APA Style

Mosca, A., Manco, M., Braghini, M. R., Cianfarani, S., Maggiore, G., Alisi, A., & Vania, A. (2024). Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites, 14(1), 71. https://doi.org/10.3390/metabo14010071

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