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Metabolites
Volume 14
Issue 1
10.3390/metabo14010029
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Systematic Review

The Potential of the Flavonoid Content of Ipomoea batatas L. as an Alternative Analog GLP-1 for Diabetes Type 2 Treatment—Systematic Review

by
Ni Kadek Santi Maha Dewi
1,2,
Yan Ramona
3,
Made Ratna Saraswati
4,
Desak Made Wihandani
5 and
I Made Agus Gelgel Wirasuta
2,6,*
1
Doctoral Study Program, Faculty of Medicine, Udayana University, Denpasar 80232, Indonesia
2
Pharmacy Department, Faculty of Mathematic and Natural Science, Udayana University, Kampus Bukit Jimbaran, Denpasar 80361, Indonesia
3
Biology Department, Faculty of Mathematic and Natural Science, Udayana University, Kampus Bukit Jimbaran, Denpasar 80361, Indonesia
4
Department of Internal Medicine, Faculty of Medicine, Udayana University, Denpasar 80232, Indonesia
5
Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar 80232, Indonesia
6
Forensic Sciences Laboratory, Institute of Forensic Sciences and Criminology, Udayana University, Kampus Bukit Jimbaran, Denpasar 80361, Indonesia
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(1), 29; https://doi.org/10.3390/metabo14010029
Submission received: 3 December 2023 / Revised: 23 December 2023 / Accepted: 26 December 2023 / Published: 31 December 2023
(This article belongs to the Special Issue Research Progress of Plant Compounds for Diabetes and Its Complications)
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Abstract

Ipomoea batatas L. (IBL) has gained significant popularity as a complementary therapy or herbal medicine in the treatment of anti-diabetes. This review seeks to explore the mechanism by which flavonoid compounds derived from IBL exert their anti-diabetic effects through the activation of GLP-1. The review article refers to the PRISMA guidelines. In order to carry out the literature search, electronic databases such as Science Direct, Crossref, Scopus, and Pubmed were utilized. The search query was based on specific keywords, including Ipomoea batatas OR sweet potato AND anti-diabetic OR hypoglycemic. After searching the databases, we found 1055 articles, but only 32 met the criteria for further review. IBL contains various compounds, including phenolic acid, flavonols, flavanols, flavones, and anthocyanins, which exhibit activity against anti-diabetes. Flavonols, flavanols, and flavones belong to a group of flavonoids that possess the ability to form complexes with AlCl3 and Ca2+. The intracellular L cells effectively retain Ca2+, leading to the subsequent release of GLP-1. Flavonols, flavones, and flavone groups have been found to strongly interact with DPP-IV, which inhibits the degradation of GLP-1. The anti-diabetic activity of IBL is attributed to the mechanism that effectively increases the duration of GLP-1 in the systemic system, thereby prolonging its half-life.
Keywords: anti-diabetic; GLP-1; Ipomoea batatas L. flavonoid; pharmacology anti-diabetic; GLP-1; Ipomoea batatas L. flavonoid; pharmacology
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MDPI and ACS Style

Dewi, N.K.S.M.; Ramona, Y.; Saraswati, M.R.; Wihandani, D.M.; Wirasuta, I.M.A.G. The Potential of the Flavonoid Content of Ipomoea batatas L. as an Alternative Analog GLP-1 for Diabetes Type 2 Treatment—Systematic Review. Metabolites 2024, 14, 29. https://doi.org/10.3390/metabo14010029

AMA Style

Dewi NKSM, Ramona Y, Saraswati MR, Wihandani DM, Wirasuta IMAG. The Potential of the Flavonoid Content of Ipomoea batatas L. as an Alternative Analog GLP-1 for Diabetes Type 2 Treatment—Systematic Review. Metabolites. 2024; 14(1):29. https://doi.org/10.3390/metabo14010029

Chicago/Turabian Style

Dewi, Ni Kadek Santi Maha, Yan Ramona, Made Ratna Saraswati, Desak Made Wihandani, and I Made Agus Gelgel Wirasuta. 2024. "The Potential of the Flavonoid Content of Ipomoea batatas L. as an Alternative Analog GLP-1 for Diabetes Type 2 Treatment—Systematic Review" Metabolites 14, no. 1: 29. https://doi.org/10.3390/metabo14010029

APA Style

Dewi, N. K. S. M., Ramona, Y., Saraswati, M. R., Wihandani, D. M., & Wirasuta, I. M. A. G. (2024). The Potential of the Flavonoid Content of Ipomoea batatas L. as an Alternative Analog GLP-1 for Diabetes Type 2 Treatment—Systematic Review. Metabolites, 14(1), 29. https://doi.org/10.3390/metabo14010029

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