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Metabolites
Volume 13
Issue 4
10.3390/metabo13040573
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Review

Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease

by
Sara Jarmakiewicz-Czaja
1,
Katarzyna Ferenc
2 and
Rafał Filip
2,3,*
1
Institute of Health Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland
2
Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland
3
Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, 35-301 Rzeszow, Poland
*
Author to whom correspondence should be addressed.
Metabolites 2023, 13(4), 573; https://doi.org/10.3390/metabo13040573
Submission received: 27 March 2023 / Revised: 13 April 2023 / Accepted: 16 April 2023 / Published: 18 April 2023
(This article belongs to the Special Issue Regulation of Oxidative Stress on Gut Microbial Homeostasis and Metabolism)
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Abstract

Inflammatory bowel disease (IBD) belongs to a group of chronic diseases characterised by periods of exacerbation and remission. Despite many studies and observations, its aetiopathogenesis is still not fully understood. The interactions of genetic, immunological, microbiological, and environmental factors can induce disease development and progression, but there is still a lack of information on these mechanisms. One of the components that can increase the risk of occurrence of IBD, as well as disease progression, is oxidative stress. Oxidative stress occurs when there is an imbalance between reactive oxygen species (ROS) and antioxidants. The endogenous and exogenous components that make up the body’s antioxidant defence can significantly affect IBD prophylaxis and reduce the risk of exacerbation by neutralising and removing ROS, as well as influencing the inflammatory state.
Keywords: antioxidants; Crohn’s disease; inflammatory bowel disease; nutrients; oxidative stress; ulcerative colitis antioxidants; Crohn’s disease; inflammatory bowel disease; nutrients; oxidative stress; ulcerative colitis

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MDPI and ACS Style

Jarmakiewicz-Czaja, S.; Ferenc, K.; Filip, R. Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease. Metabolites 2023, 13, 573. https://doi.org/10.3390/metabo13040573

AMA Style

Jarmakiewicz-Czaja S, Ferenc K, Filip R. Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease. Metabolites. 2023; 13(4):573. https://doi.org/10.3390/metabo13040573

Chicago/Turabian Style

Jarmakiewicz-Czaja, Sara, Katarzyna Ferenc, and Rafał Filip. 2023. "Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease" Metabolites 13, no. 4: 573. https://doi.org/10.3390/metabo13040573

APA Style

Jarmakiewicz-Czaja, S., Ferenc, K., & Filip, R. (2023). Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease. Metabolites, 13(4), 573. https://doi.org/10.3390/metabo13040573

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