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Review

The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies

by 1,2,* and 1,3,4,*
1
Department of Physiology and Biophysics, Dalhousie University, Halifax, NS B3H 4R2, Canada
2
Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah 21423, Saudi Arabia
3
Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada
4
Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Markus R. Meyer
Metabolites 2022, 12(6), 541; https://doi.org/10.3390/metabo12060541
Received: 11 March 2022 / Revised: 31 May 2022 / Accepted: 10 June 2022 / Published: 14 June 2022
Abnormal blood coagulation or coagulopathy is a common manifestation of many pathological conditions. It occurs when there is an imbalance between the activities of the coagulation system and the fibrinolytic system, leading to excessive or impaired intravascular blood clot formation, which can disturb blood flow causing ischemia or hemorrhage in the affected tissues. A growing body of evidence has demonstrated blood coagulation abnormalities in association with cannabinoid use, suggesting the involvement of the endogenous cannabinoid system (ECS) in modulating blood coagulation. However, the evidence in the literature has been controversial on whether cannabinoids promote or inhibit blood coagulation. The ECS has been extensively studied in recent years for its potential as a therapeutic target for many diseases. This review provides a brief introduction to the ECS and discusses the reported anticoagulatory and procoagulatory effects of various cannabinoids, highlighting some possible mechanisms that might underlie the observed effects. Understanding the coagulatory effects of cannabinoids and the interaction between the coagulation system and the ECS is vital for developing novel therapeutics for coagulopathies. View Full-Text
Keywords: cannabinoids; endocannabinoids; endocannabinoid system; marijuana; cannabis; coagulopathy; blood coagulation; thrombosis; hemorrhage cannabinoids; endocannabinoids; endocannabinoid system; marijuana; cannabis; coagulopathy; blood coagulation; thrombosis; hemorrhage
MDPI and ACS Style

Khayat, W.; Lehmann, C. The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies. Metabolites 2022, 12, 541. https://doi.org/10.3390/metabo12060541

AMA Style

Khayat W, Lehmann C. The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies. Metabolites. 2022; 12(6):541. https://doi.org/10.3390/metabo12060541

Chicago/Turabian Style

Khayat, Wujood, and Christian Lehmann. 2022. "The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies" Metabolites 12, no. 6: 541. https://doi.org/10.3390/metabo12060541

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