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Article

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

1
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, Finland
2
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland
3
Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70210 Kuopio, Finland
4
Department of Medicine, Kuopio University Hospital, 70210 Kuopio, Finland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Manfredi Rizzo
Metabolites 2022, 12(1), 69; https://doi.org/10.3390/metabo12010069
Received: 16 December 2021 / Revised: 10 January 2022 / Accepted: 10 January 2022 / Published: 12 January 2022
(This article belongs to the Section Endocrinology and Clinical Metabolic Research)
Large population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type2 diabetes. Our study included 8749 Finnish men without diabetes at baseline recruited from the Metabolic Syndrome in Men (METSIM) cohort. We used a questionnaire to measure leisure-time PA. Metabolites were measured in 7271 men as a part of Metabolon’s untargeted Discovery HD4 platform using ultrahigh-performance liquid chromatography–tandem mass spectrometry. We found 198 metabolites significantly associated with PA. Several of these metabolites were novel including especially steroids, amino acids, imidazoles, carboxylic acids, and hydroxy acids. Increased PA was significantly associated with high levels of choline plasmalogens, lysophosphatidylcholines, polyunsaturated fatty acids, carotenoids, long chain acylcarnitines, imidazoles, bilirubins, aryl sulfates, hydroxy acids, indolepropionate, and indolelactate. Several of these metabolites have been previously associated with a decreased risk of type 2 diabetes and with a healthy diet. Our population-based study shows that the metabolite signature of increased PA includes multiple metabolic pathways and is associated with better adherence to a healthy lifestyle. View Full-Text
Keywords: physical activity; type 2 diabetes; insulin sensitivity; insulin secretion; metabolites; healthy diet physical activity; type 2 diabetes; insulin sensitivity; insulin secretion; metabolites; healthy diet
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MDPI and ACS Style

Kemppainen, S.M.; Fernandes Silva, L.; Lankinen, M.A.; Schwab, U.; Laakso, M. Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men. Metabolites 2022, 12, 69. https://doi.org/10.3390/metabo12010069

AMA Style

Kemppainen SM, Fernandes Silva L, Lankinen MA, Schwab U, Laakso M. Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men. Metabolites. 2022; 12(1):69. https://doi.org/10.3390/metabo12010069

Chicago/Turabian Style

Kemppainen, Susanna Maria, Lilian Fernandes Silva, Maria Anneli Lankinen, Ursula Schwab, and Markku Laakso. 2022. "Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men" Metabolites 12, no. 1: 69. https://doi.org/10.3390/metabo12010069

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