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Article

Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice

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Neuroscience Department, Wellesley College, Wellesley, MA 02481, USA
2
Program in Molecular Medicine, Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
3
Department of Health Sciences Research & Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Giancarlo Panzica, Stefano Gotti and Paloma Collado Guirao
Metabolites 2021, 11(8), 499; https://doi.org/10.3390/metabo11080499
Received: 10 June 2021 / Revised: 24 July 2021 / Accepted: 27 July 2021 / Published: 30 July 2021
(This article belongs to the Special Issue Neuroendocrine Control of Energy Metabolism)
A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that gut microbiota regulates energy homeostasis, it is unclear if gut microbiota is associated with estradiol regulation of metabolism. In this study, we tested if estradiol-mediated protection from high-fat diet (HFD)-induced obesity and metabolic changes are associated with longitudinal alterations in gut microbiota in female mice. Ovariectomized adult mice with vehicle or estradiol (E2) implants were fed chow for two weeks and HFD for four weeks. As reported previously, E2 increased energy expenditure, physical activity, insulin sensitivity, and whole-body glucose turnover. Interestingly, E2 decreased the tight junction protein occludin, suggesting E2 affects gut epithelial integrity. Moreover, E2 increased Akkermansia and decreased Erysipleotrichaceae and Streptococcaceae. Furthermore, Coprobacillus and Lactococcus were positively correlated, while Akkermansia was negatively correlated, with body weight and fat mass. These results suggest that changes in gut epithelial barrier and specific gut microbiota contribute to E2-mediated protection against diet-induced obesity and metabolic dysregulation. These findings provide support for the gut microbiota as a therapeutic target for treating estrogen-dependent metabolic disorders in women. View Full-Text
Keywords: diabetes; estrogens; gut permeability/integrity; insulin sensitivity; Akkermansia; gut microbiome diabetes; estrogens; gut permeability/integrity; insulin sensitivity; Akkermansia; gut microbiome
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MDPI and ACS Style

Acharya, K.D.; Noh, H.L.; Graham, M.E.; Suk, S.; Friedline, R.H.; Gomez, C.C.; Parakoyi, A.E.R.; Chen, J.; Kim, J.K.; Tetel, M.J. Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice. Metabolites 2021, 11, 499. https://doi.org/10.3390/metabo11080499

AMA Style

Acharya KD, Noh HL, Graham ME, Suk S, Friedline RH, Gomez CC, Parakoyi AER, Chen J, Kim JK, Tetel MJ. Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice. Metabolites. 2021; 11(8):499. https://doi.org/10.3390/metabo11080499

Chicago/Turabian Style

Acharya, Kalpana D., Hye L. Noh, Madeline E. Graham, Sujin Suk, Randall H. Friedline, Cesiah C. Gomez, Abigail E. R. Parakoyi, Jun Chen, Jason K. Kim, and Marc J. Tetel. 2021. "Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice" Metabolites 11, no. 8: 499. https://doi.org/10.3390/metabo11080499

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