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Review

Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease

by 1,2,†, 2,† and 2,*
1
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China
2
Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Walter Wahli
Metabolites 2021, 11(5), 320; https://doi.org/10.3390/metabo11050320
Received: 6 April 2021 / Revised: 10 May 2021 / Accepted: 12 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Steroids in Non-alcoholic Fatty Liver Disease)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid hormones are important regulators of lipid homeostasis through fine tuning the expression of genes related to lipid synthesis, export, and metabolism. Dysregulation of such pathways has been implicated in the pathogenesis of NAFLD. The aim of this review is to clarify the potential impact of steroid hormones on NAFLD. We also highlight potential interventions through modulating steroid hormone levels or the activities of their cognate receptors as therapeutic strategies for preventing NAFLD. View Full-Text
Keywords: NAFLD; steroid hormone; steroid hormone receptor NAFLD; steroid hormone; steroid hormone receptor
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MDPI and ACS Style

Yang, M.; Ma, F.; Guan, M. Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease. Metabolites 2021, 11, 320. https://doi.org/10.3390/metabo11050320

AMA Style

Yang M, Ma F, Guan M. Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease. Metabolites. 2021; 11(5):320. https://doi.org/10.3390/metabo11050320

Chicago/Turabian Style

Yang, Meng, Feng Ma, and Min Guan. 2021. "Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease" Metabolites 11, no. 5: 320. https://doi.org/10.3390/metabo11050320

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