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Brief Report

Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial

1
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
2
Universitat Rovira i Virgili, Departament of Biochemistry and Biotechnology, Human Nutrition Unit, 43201 Reus, Spain
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Institut d’Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain
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Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain
5
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain
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IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain
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Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, University of Malaga (IBIMA), 29010 Malaga, Spain
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Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), 43201 Reus, Spain
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Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
10
Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
11
Channing Division for Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
12
The Broad Institute of Harvard and MIT, Boston, MA 02142, USA
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Department of Internal Medicine, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
14
Lipid Clinic, Department of Endocrinology and Nutrition, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
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Cardiovascular and Nutrition Research Group, Institut de Recerca Hospital del Mar, 08036 Barcelona, Spain
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Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA 02132, USA
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Department of Cardiology, University Hospital of Alava, 01009 Vitoria, Spain
18
Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Service of Preventive Medicine, Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canary Health Service, 35001 Las Palmas de Gran Canaria, Spain
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Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
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Department of Preventive Medicine and Public Health, School of Medicine, University of Málaga, 29010 Málaga, Spain
21
Nutrition Unit, University Hospital of Sant Joan de Reus, 43204 Reus, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Senior authors.
Academic Editors: Gloria Alvarez-Llamas and Marta Martin-Lorenzo
Metabolites 2021, 11(5), 306; https://doi.org/10.3390/metabo11050306
Received: 8 April 2021 / Revised: 6 May 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case–control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR for 1 SD increase: 1.28; 95% CI: 1.06, 1.53). The present findings do not support a role of the glycolysis pathway in the pathogenesis of AF. However, the increased risk of HF associated with phosphoglycerate requires further studies. View Full-Text
Keywords: glycolysis; heart failure; atrial fibrillation; PREDIMED study glycolysis; heart failure; atrial fibrillation; PREDIMED study
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MDPI and ACS Style

Becerra-Tomás, N.; Ruiz-Canela, M.; Hernández-Alonso, P.; Bulló, M.; Li, J.; Guasch-Ferré, M.; Toledo, E.; Clish, C.B.; Estruch, R.; Ros, E.; Fitó, M.; Lee, C.-H.; Pierce, K.; Arós, F.; Serra-Majem, L.; Liang, L.; Razquin, C.; Gómez-Gracia, E.; Martínez-González, M.A.; Hu, F.B.; Corella, D.; Salas-Salvadó, J. Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites 2021, 11, 306. https://doi.org/10.3390/metabo11050306

AMA Style

Becerra-Tomás N, Ruiz-Canela M, Hernández-Alonso P, Bulló M, Li J, Guasch-Ferré M, Toledo E, Clish CB, Estruch R, Ros E, Fitó M, Lee C-H, Pierce K, Arós F, Serra-Majem L, Liang L, Razquin C, Gómez-Gracia E, Martínez-González MA, Hu FB, Corella D, Salas-Salvadó J. Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites. 2021; 11(5):306. https://doi.org/10.3390/metabo11050306

Chicago/Turabian Style

Becerra-Tomás, Nerea, Miguel Ruiz-Canela, Pablo Hernández-Alonso, Mònica Bulló, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary B. Clish, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Fernando Arós, Lluís Serra-Majem, Liming Liang, Cristina Razquin, Enrique Gómez-Gracia, Miguel A. Martínez-González, Frank B. Hu, Dolores Corella, and Jordi Salas-Salvadó. 2021. "Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial" Metabolites 11, no. 5: 306. https://doi.org/10.3390/metabo11050306

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