High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples
Abstract
:1. Introduction
2. Results and Discussion
2.1. Two-Phase Acoustic Calibration
2.2. Two-Phase AEMS Performance
2.3. Case Study, Fentanyl Analysis from Urine
3. Materials and Methods
3.1. Reagents and Materials
3.2. Sample Prepration
3.3. AEMS System
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Concentration (ng/mL) | CV (%) | Accuracy (%) | |
---|---|---|---|
0 | - | - | |
1 | 13.4 | 98.8 | |
Calibrants | 3 | 9.7 | 94.4 |
10 | 6.6 | 101.6 | |
30 | 9.0 | 100.0 | |
100 | 8.9 | 100.0 | |
2 | 8.5 | 106.8 | |
QC | 15 | 5.3 | 106.3 |
75 | 4.6 | 108.3 |
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Guo, Y.; Forbush, M.; Covey, T.R.; Ghislain, L.; Liu, C. High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples. Metabolites 2021, 11, 789. https://doi.org/10.3390/metabo11110789
Guo Y, Forbush M, Covey TR, Ghislain L, Liu C. High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples. Metabolites. 2021; 11(11):789. https://doi.org/10.3390/metabo11110789
Chicago/Turabian StyleGuo, Yuzhu, Michael Forbush, Thomas R. Covey, Lucien Ghislain, and Chang Liu. 2021. "High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples" Metabolites 11, no. 11: 789. https://doi.org/10.3390/metabo11110789