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Article

In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels

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Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA
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Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada
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Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
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Department of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada
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Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada
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Department of Chemistry, Faculty of Sciences, Sherbrooke, QC J1K 2R1, Canada
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Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada
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Department of Pediatrics & Department of Psychiatry, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada
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Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA
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Author to whom correspondence should be addressed.
Academic Editor: Wilfried Le Goff
Metabolites 2021, 11(10), 657; https://doi.org/10.3390/metabo11100657
Received: 3 September 2021 / Revised: 21 September 2021 / Accepted: 24 September 2021 / Published: 28 September 2021
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (p = 0.003), and non-significantly with HDL-C (p = 0.06) and TL (p = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (p = 0.04), LDL-C (p = 0.04), and TL (p = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data. View Full-Text
Keywords: dyslipidemia; fetal programing; lipid metabolism; NAFLD; persistent organic pollutants dyslipidemia; fetal programing; lipid metabolism; NAFLD; persistent organic pollutants
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MDPI and ACS Style

Boutot, M.E.; Whitcomb, B.W.; Abdelouahab, N.; Baccarelli, A.A.; Boivin, A.; Caku, A.; Gillet, V.; Martinez, G.; Pasquier, J.-C.; Zhu, J.; Takser, L.; St-Cyr, L.; Suvorov, A. In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels. Metabolites 2021, 11, 657. https://doi.org/10.3390/metabo11100657

AMA Style

Boutot ME, Whitcomb BW, Abdelouahab N, Baccarelli AA, Boivin A, Caku A, Gillet V, Martinez G, Pasquier J-C, Zhu J, Takser L, St-Cyr L, Suvorov A. In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels. Metabolites. 2021; 11(10):657. https://doi.org/10.3390/metabo11100657

Chicago/Turabian Style

Boutot, Maegan E., Brian W. Whitcomb, Nadia Abdelouahab, Andrea A. Baccarelli, Amélie Boivin, Artuela Caku, Virginie Gillet, Guillaume Martinez, Jean-Charles Pasquier, Jiping Zhu, Larissa Takser, Lindsay St-Cyr, and Alexander Suvorov. 2021. "In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels" Metabolites 11, no. 10: 657. https://doi.org/10.3390/metabo11100657

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