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Open AccessArticle

Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle

1
Department of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, Brazil
2
EMBRAPA Instrumentação, XV de Novembro 1452, São Carlos 13560-970, Brazil
3
Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, Denmark
4
Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(2), 58; https://doi.org/10.3390/metabo10020058
Received: 23 December 2019 / Revised: 22 January 2020 / Accepted: 27 January 2020 / Published: 6 February 2020
To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using Longissimus lumborum (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low growth, LG; high precocity, HP; low precocity, LP). Genetic potential for growth affected muscle protein and energetic metabolism. HG animals had a high concentration of arginine, carnosine, and leucine compared to LG animals. HP animals presented a high concentration of glutamine, betaine, creatinine, isoleucine, carnitine, acetyl carnitine, and lower levels of glucose compared to LP animals, affecting protein and fatty acid metabolism. Intensity of selection (high or low) was correlated with changes in protein metabolism, and the type of selection (growth or precocity) affected fat metabolism. In conclusion, both HG and HP appear to be correlated with a high concentration of protein metabolites and changes in protein metabolic pathways, while selection for precocity is more correlated with changes in fat metabolism compared to animals selected for growth.
Keywords: genetic selection; growth; metabolomics; muscle metabolites; NMR spectroscopy; Nellore; precocity genetic selection; growth; metabolomics; muscle metabolites; NMR spectroscopy; Nellore; precocity
MDPI and ACS Style

Cônsolo, N.R.B.; Silva, J.; Buarque, V.L.M.; Higuera-Padilla, A.; Barbosa, L.C.G.S.; Zawadzki, A.; Colnago, L.A.; Netto, A.S.; Gerrard, D.E.; Silva, S.L. Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle. Metabolites 2020, 10, 58.

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