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Article

Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress

1
Department of Fundamental and Applied Neurobiology, V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Kropotkinsky Per. 23, 119034 Moscow, Russia
2
Department of Biology, Shenzhen MSU-BIT University, Ruyi Rd. 299, Shenzhen 518172, China
3
School of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
4
Mental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, Russia
5
Department of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
6
Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Helen D. Skaltsa
Sci. Pharm. 2022, 90(3), 50; https://doi.org/10.3390/scipharm90030050
Received: 8 June 2022 / Revised: 29 July 2022 / Accepted: 9 August 2022 / Published: 23 August 2022
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicants for this role. We investigated the antidepressant effect of neuropeptide Y (NY), alone and in combination with clomipramine, in models of acute and chronic stress induced by ultrasound of variable frequencies. Rats were divided into the following groups: the control group, stress group, and stress groups with intranasal administration of NY (100 μg/kg) or clomipramine (7.5 mg/kg), or their combination. Rat behavior was evaluated using a sucrose preference test and forced swimming test in an acute stress model, and a sucrose preference test, forced swimming test, social interaction test, open field test, and Morris water maze test in a chronic stress model. The results of our experiment demonstrated a protective effect of intranasal NY in a model of acute stress, which was comparable to the antidepressant effect of clomipramine. When the same dose was chronically administered, NY also demonstrated an antidepressant action, although expressed in a lesser degree than clomipramine. The combination of NY and clomipramine was much less effective in the chronic stress paradigm compared to the separated drug administration, but was just as effective in the acute stress paradigm. Until now, there was no convincing evidence for the efficacy of the chronic administration of neuropeptide Y; we demonstrated its effectiveness in the animal model of depressive-like behavior. However, our hypothesis that neuropeptide Y can enhance the effect of a classical antidepressant was not confirmed. View Full-Text
Keywords: neuropeptide Y; antidepressants; clomipramine; drug combination; intranasal administration; acute stress; chronic stress; depressive-like behavior; depression; rats neuropeptide Y; antidepressants; clomipramine; drug combination; intranasal administration; acute stress; chronic stress; depressive-like behavior; depression; rats
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MDPI and ACS Style

Andriushchenko, N.; Nebogina, K.; Zorkina, Y.; Abramova, O.; Zubkov, E.; Ochneva, A.; Ushakova, V.; Pavlov, K.; Gurina, O.; Chekhonin, V.; Morozova, A. Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress. Sci. Pharm. 2022, 90, 50. https://doi.org/10.3390/scipharm90030050

AMA Style

Andriushchenko N, Nebogina K, Zorkina Y, Abramova O, Zubkov E, Ochneva A, Ushakova V, Pavlov K, Gurina O, Chekhonin V, Morozova A. Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress. Scientia Pharmaceutica. 2022; 90(3):50. https://doi.org/10.3390/scipharm90030050

Chicago/Turabian Style

Andriushchenko, Nika, Kira Nebogina, Yana Zorkina, Olga Abramova, Eugene Zubkov, Aleksandra Ochneva, Valeria Ushakova, Konstantin Pavlov, Olga Gurina, Vladimir Chekhonin, and Anna Morozova. 2022. "Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress" Scientia Pharmaceutica 90, no. 3: 50. https://doi.org/10.3390/scipharm90030050

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