Next Article in Journal
Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome
Next Article in Special Issue
Preliminary Protocol Development of a HPLC-TBARS-EVSC (Ex Vivo Stratum Corneum) Assay for Skin Research: Application in a Sunscreen System
Previous Article in Journal
Evaluation of Topical Anti-Inflammatory Effects of a Gel Formulation with Plantago Lanceolata, Achillea Millefolium, Aesculus Hippocastanum and Taxodium Distichum
Previous Article in Special Issue
Is the Botryococcus braunii Dry Biomass an Adjuvant for Anti-UVB Topical Formulations?

Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review

Aesthetics and Cosmetics Course, Paulista University, São Paulo 04709-11, Brazil
Department of Pharmacy, School of Pharmaceutical Science, University of São Paulo, São Paulo 05508-000, Brazil
Faculty of Pharmacy and Biochemistry, Major National University of São Marcos, Lima 15081, Peru
Author to whom correspondence should be addressed.
The contributions of these authors were equal.
Sci. Pharm. 2020, 88(2), 27;
Received: 29 February 2020 / Revised: 6 April 2020 / Accepted: 15 April 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Functional Ingredients in Topical and Transdermal Delivery Systems)
The skin is constantly exposed to various environmental stresses, in particular to the damage caused by pollution and ultraviolet radiation (UV), and as a consequence, the horny extract can be negatively impacted by the harmful influence of some of its surface components. The mechanisms involved in the degradation processes promoted by UV radiation are driven by the direct absorption of radiation via cellular chromophores, the formation of excited states and the consequent chemical reactions, or even by the photosensitization mechanisms, in which UV light is absorbed by the sensitizers that are excited and their reactions promote the formation of reactive oxygen species (ROS). The mechanisms of polluting agents are not yet fully understood, however, they indicate that one of the main mechanisms involved is oxidative stress by lipid peroxidation, with the ability to promote damage to the composition of sebum, the quality of the stratum corneum and also, promote aging skin. Recent studies demonstrate the potential of antioxidant agents, with an emphasis on products of natural origin, which try to promote the maintenance of the physiological balance of the skin. View Full-Text
Keywords: antioxidant; permeation; pollution; solar radiation; skin antioxidant; permeation; pollution; solar radiation; skin
Show Figures

Graphical abstract

MDPI and ACS Style

Azevedo Martins, T.E.; Sales de Oliveira Pinto, C.A.; Costa de Oliveira, A.; Robles Velasco, M.V.; Gorriti Guitiérrez, A.R.; Cosquillo Rafael, M.F.; Tarazona, J.P.H.; Retuerto-Figueroa, M.G. Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review. Sci. Pharm. 2020, 88, 27.

AMA Style

Azevedo Martins TE, Sales de Oliveira Pinto CA, Costa de Oliveira A, Robles Velasco MV, Gorriti Guitiérrez AR, Cosquillo Rafael MF, Tarazona JPH, Retuerto-Figueroa MG. Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review. Scientia Pharmaceutica. 2020; 88(2):27.

Chicago/Turabian Style

Azevedo Martins, Tércio E., Claudinéia A. Sales de Oliveira Pinto, Andressa Costa de Oliveira, Maria V. Robles Velasco, Arilmí R. Gorriti Guitiérrez, Martha F. Cosquillo Rafael, Jossimar P.H. Tarazona, and Mónica G. Retuerto-Figueroa 2020. "Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review" Scientia Pharmaceutica 88, no. 2: 27.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop