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Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review

1
Aesthetics and Cosmetics Course, Paulista University, São Paulo 04709-11, Brazil
2
Department of Pharmacy, School of Pharmaceutical Science, University of São Paulo, São Paulo 05508-000, Brazil
3
Faculty of Pharmacy and Biochemistry, Major National University of São Marcos, Lima 15081, Peru
*
Author to whom correspondence should be addressed.
The contributions of these authors were equal.
Sci. Pharm. 2020, 88(2), 27; https://doi.org/10.3390/scipharm88020027
Received: 29 February 2020 / Revised: 6 April 2020 / Accepted: 15 April 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Functional Ingredients in Topical and Transdermal Delivery Systems)
The skin is constantly exposed to various environmental stresses, in particular to the damage caused by pollution and ultraviolet radiation (UV), and as a consequence, the horny extract can be negatively impacted by the harmful influence of some of its surface components. The mechanisms involved in the degradation processes promoted by UV radiation are driven by the direct absorption of radiation via cellular chromophores, the formation of excited states and the consequent chemical reactions, or even by the photosensitization mechanisms, in which UV light is absorbed by the sensitizers that are excited and their reactions promote the formation of reactive oxygen species (ROS). The mechanisms of polluting agents are not yet fully understood, however, they indicate that one of the main mechanisms involved is oxidative stress by lipid peroxidation, with the ability to promote damage to the composition of sebum, the quality of the stratum corneum and also, promote aging skin. Recent studies demonstrate the potential of antioxidant agents, with an emphasis on products of natural origin, which try to promote the maintenance of the physiological balance of the skin. View Full-Text
Keywords: antioxidant; permeation; pollution; solar radiation; skin antioxidant; permeation; pollution; solar radiation; skin
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Azevedo Martins, T.E.; Sales de Oliveira Pinto, C.A.; Costa de Oliveira, A.; Robles Velasco, M.V.; Gorriti Guitiérrez, A.R.; Cosquillo Rafael, M.F.; Tarazona, J.P.H.; Retuerto-Figueroa, M.G. Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review. Sci. Pharm. 2020, 88, 27.

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