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Diseases 2018, 6(3), 78; https://doi.org/10.3390/diseases6030078

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling

1
Department of Psychiatry, University College Cork, T12 DC4A Cork, Ireland
2
APC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland
3
Department of Anatomy and Neuroscience, University College Cork, T12 XF62 Cork, Ireland
*
Author to whom correspondence should be addressed.
Received: 26 July 2018 / Revised: 23 August 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Gut Microbiome and Human Diseases)
Full-Text   |   PDF [422 KB, uploaded 6 September 2018]   |  

Abstract

The microbiome gut brain (MGB) axis consists of bidirectional routes of communication between the gut and the brain. It has emerged as a potential therapeutic target for multiple medical specialties including psychiatry. Significant numbers of preclinical trials have taken place with some transitioning to clinical studies in more recent years. Some positive results have been reported secondary to probiotic administration in both healthy populations and specific patient groups. This review aims to summarise the current understanding of the MGB axis and the preclinical and clinical findings relevant to psychiatry. Significant differences have been identified between the microbiome of patients with a diagnosis of depressive disorder and healthy controls. Similar findings have occurred in patients diagnosed with bipolar affective disorder and irritable bowel syndrome. A probiotic containing Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium bifidum produced a clinically measurable symptom improvement in patients with depressive disorder. To date, some promising results have suggested that probiotics could play a role in the treatment of stress-related psychiatric disease. However, more well-controlled clinical trials are required to determine which clinical conditions are likely to benefit most significantly from this novel approach. View Full-Text
Keywords: psychiatry; gut microbiome; probiotics psychiatry; gut microbiome; probiotics
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Scriven, M.; Dinan, T.G.; Cryan, J.F.; Wall, M. Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Diseases 2018, 6, 78.

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