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Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma

1
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan
2
Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirogane, Minato-ku, Tokyo 108-8641, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen L. Chan
Diseases 2015, 3(4), 260-281; https://doi.org/10.3390/diseases3040260
Received: 24 August 2015 / Revised: 11 October 2015 / Accepted: 13 October 2015 / Published: 22 October 2015
(This article belongs to the Special Issue Targeted Therapy of Hepatocellular Carcinoma: Present and Future)
Hepatocellular carcinoma (HCC) is highly resistant to currently available chemotherapeutic agents. The clinical outcome of HCC treatment remains unsatisfactory. Therefore, new effective and well-tolerated therapy strategies are needed. Natural products are excellent sources for the development of new medications for disease treatment. Recently, we and other researchers have suggested that the combined effect of natural products may improve the effect of chemotherapy treatments against the proliferation of cancer cells. In addition, many combination treatments with natural products augmented intracellular reactive oxygen species (ROS). In this review we will demonstrate the synergistic anticancer effects of a combination of natural products with chemotherapeutic agents or natural products against human HCC and provide new insight into the development of novel combination therapies against HCC. View Full-Text
Keywords: hepatocellular carcinoma (HCC); natural products; chemotherapeutic agents; combination treatment; synergistic anticancer effect; reactive oxygen species (ROS) hepatocellular carcinoma (HCC); natural products; chemotherapeutic agents; combination treatment; synergistic anticancer effect; reactive oxygen species (ROS)
MDPI and ACS Style

Kojima-Yuasa, A.; Huang, X.; Matsui-Yuasa, I. Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma. Diseases 2015, 3, 260-281.

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