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The Effects of Vitamin D Supplementation on Pulmonary Function of Chronic Obstructive Pulmonary Disease Patients, before and after Clinical Trial

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Department of Pulmonary, Iran University of Medical Sciences, Tehran 14174, Iran
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Department of Pulmonary, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Diseases 2015, 3(4), 253-259; https://doi.org/10.3390/diseases3040253
Received: 3 July 2015 / Accepted: 8 October 2015 / Published: 16 October 2015
Vitamin D has several extra calcemic effects. Vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients but little is known about it’s association with lung function. Objective: To investigate whether supplementation with vitamin D could improve pulmonary function in COPD patients. Design: Before and after, double center, clinical trial. Setting: Hazrat Rasoul University Hospital, Tehran, and Imam Khomaini University Hospital, Ahvaz, Iran. Participants: 24 patients with mild to very severe COPD. Intervention: Loading dose of 300,000–600,000 International Units (IU) of vitamin D, then 50000 IU weekly for 12 weeks. Measurements: The outcomes included forced expiratory volume in one second (FEV1), forced vital capacity (FVC), vital capacity (VC), forced expiratory flow between 25%–75% of forced vital capacity (FEF 25%–75%), exercise capacity according to the six minute walk test(6MWT) and the saturation of oxygen during exercise. Results: The mean FEV1 (p-value = 0.866), FVC (p-value = 0.475) and VC (p-value = 0.425) were not significantly different before and after intervention. FEF 25%–75% did not improve with this intervention (p-value = 0.555). The vitamin D supplementation did not have any significant effect on the exercise capacity (p-value=0.175) or the saturation of oxygen (p-value = 0.635). Conclusion: Pulmonary function and exercise capacity did not improve with vitamin D supplementation in COPD patients. View Full-Text
Keywords: chronic obstructive pulmonary disease; vitamin D chronic obstructive pulmonary disease; vitamin D
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Moosavi, S.A.J.; Shoushtari, M.H. The Effects of Vitamin D Supplementation on Pulmonary Function of Chronic Obstructive Pulmonary Disease Patients, before and after Clinical Trial. Diseases 2015, 3, 253-259.

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